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| Retrospective cohort study of the effect of Chinese herbal decoction combined with standard therapyin the treatment of acute coronary syndrome after percutaneous coronary intervention |
| Hits 578 Download times 351 Received:August 15, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.11.01 |
| Key Words
acute coronary syndrome;percutaneous coronary intervention;Chinese herbal decoction;readmission;retrospective cohort study |
| Author Name | Affiliation | E-mail | | ZHANG Hui | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | FENG He | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Jingyang | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yijia | Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | PANG Jianzhong | Department of Cardiology, Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | XU Qiang | Department of Cardiology, Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | tcmxuqiang@hotmail.com |
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| Abstract
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| [Objective] To investigate the effect of earlier use Chinese herbal decoction combined with standard therapy on readmission of patients with acute coronary syndrome (ACS) after emergencypercutaneous coronary intervention (PCI),and to provide evidence-based basis for early intervention of traditional Chinese medicine after PCI.[Methods] A real world retrospective cohort study was adopted. All patients diagnosed with ACS and accepted emergency PCI in second teaching hospital of tianjin university of traditional Chinese medicine from January 2019 to August 2021 were included. Basic clinical data,coronary angiography and intervention data,as well as therapeutic schedule were collected readmission up to April 2022 was followed up. According to the difference of actual therapeutic schedule,patients were divided into standard therapy group (non-exposed group) and Chinese herbal decoction combined with standard therapy group (exposed group). All-cause readmission was taken as the primary efficacy indicator,then readmission for cardiac events, readmission for stroke and readmission for digestive tract injury were taken as the secondary efficacy indicators. The prognostic differences between two therapeutic schedules were comprehensively analyzed through Cox regression.[Results] A total of 232 patients with ACS after emergency PCI were selected,including 126 patients (54.31%) in exposed group and 106 patients (45.69%) in non-exposed group. Multivariate Cox regression analysis showed that,after adjusting for potential confounding factors,compared with non-exposed group,the risk of readmission for cardiac events in exposed group decreased by 59%[HR=0.41,95%CI(0.21,0.81),P<0.05]. There was no significant difference in all-cause readmission,readmission for stroke or readmission for digestive tract disease between the two groups (P>0.05).[Conclusion] Earlier use Chinese herbal decoction combined with standard therapyin patients with acute coronary syndrome after emergency PCI can reduce the risk of readmission for cardiac events significantly,without increasing the risk of readmission for digestive tract injury or stroke. |
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