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| Modern research evolvements of Suanzaoren Decoction in treating insomnia by regulating circadian rhythm |
| Hits 597 Download times 471 Received:July 25, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.11.21 |
| Key Words
Suanzaoren Decoction;circadian rhythm;insomnia;review |
| Author Name | Affiliation | E-mail | | ZHAO Kui | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Zhe | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XIA Xueping | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SHENG Xin | Department of Nephropathy, First Teaching Hostipal of Tianjin University of Traditional Chinese Medicinee, Tianjin 300381, China | | | PANG Chenxu | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | BIAN Yuhong | College of Integrated Traditional Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | bianyuhong_2012@163.com |
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| Abstract
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| Insomnia is a common clinical condition characterized by difficulty initiating or maintaining sleep and accompanied by symptoms such as irritability or fatigue when awake. Some Western medicine can relieve insomnia to a certain extent,but there are many adverse reactions,and even after long-term use,tolerance and dependence on the drugs may be formed. Suanzaoren Decoction,as a classic prescription for the treatment of insomnia,is highly praised by many physicians for its significant clinical efficacy and no side effects. The circadian rhythm is closely related to vital activities,and the destruction of the circadian rhythm will lead to changes in sleep,mood and so on.A large number of experimental studies indicate that Suanzaoren Decoction plays a role in the treatment of insomnia by regulating the circadian rhythm of mammals. This article aims to sort out the related fundamental experiment literatures of Suanzaoren Decoction in the treatment of insomnia by regulating the circadian rhythm and introduce that Suanzaoren Decoction regulates the expression of related genes, neurotransmitters and the irreceptors,adjusts the peptidergic neuronsin the suprachiasmatic nucleus of the hypothalamus, a strocytes and zeitgebersto regulatehecircadian rhythmfurther and achieve the effect of treating in somniain the end. We hope to provide new ideas and directions for the advanced exploration of the mechanism that Suanzaoren Decoction treats insomnia. |
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