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| Analysis of the research trend of glycyrrhetic acid based on bibliometrics |
| Hits 510 Download times 401 Received:October 13, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.12.07 |
| Key Words
glycyrrtetinic acid;bibliometrics;liver targeted;COVID-19;corticosteroid like effect |
| Author Name | Affiliation | E-mail | | WANG Yue | State Key Laboratory of Componen-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | XU Dong | State Key Laboratory of Componen-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Kuntang | State Key Laboratory of Componen-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Yibing | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | sociciso@gmail.com | | CUI Yuanlu | State Key Laboratory of Componen-based Chinese Medicine, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | cuiyl@tju.edu.cn |
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| Abstract
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| [Objective] In order to systematically analyze the bibliometric characteristics of glycyrrhetinic acid related research,explore the research hotspot and development trend of glycyrrhetinic acid in the world. [Methods] This paper takes the Web of Science (WOS) core collection database as the data source to retrieve the articles and reviews on glycyrrhetinic acid,and then the VOS viewer software and the Bibliometrix package in the R language environment were used for visual analysis of publications,organizations,journals,highly cited papers and keywords. [Results] The results showed that a total of 1845 literatures on glycyrrhetinic acid were included,and the number of publications on glycyrrhetinic acid showes a generally increasing trend over time. Institutional analysis indicated that institutions from China made the greatest contribution to glycyrrhetinic acid research,particularly the China Pharmaceutical University, which has the largest number of publications and citations,and has a strong scientific research strength. The most widely published journal is Biological & Pharmaceutical Bulletin,and the related research of glycyrrhetinic acid is favored by the journals of pharmacology and chemistry. Keyword analysis revealed that the ant-inflammatory,antiviral,hepatoprotective and anticancer pharmacological activities of glycyrrhetinic acid and the research on live-targeted preparations of glycyrrhetinic acid are the current hotspots. [Conclusion] It is further speculated that the study on the structure modification of glycyrrhetinic acid as the parent nucleus and the live-targeted nan-preparation have great development prospects,and glycyrrhetinic acid may be a potential therapeutic drug of novel coronavirus disease 2019(COVI-19). This can provide a reference for future research on glycyrrhetinic acid. |
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