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| Based on patent network to explore the core drug group and the molecular mechanism with traditional Chinese medicine for prevention and treatment of diabetes mellitus |
| Hits 462 Download times 924 Received:September 21, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2022.12.19 |
| Key Words
diabetes mellitus;compatibility law;mechanism of action;data mining;network pharmacology |
| Author Name | Affiliation | E-mail | | PAN Jianhui | Tianjin Chest Hospital, Tianjin 300222, China | | | SUN Xingyi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Chang | Tianjin Medical University, Tianjin 300203, China | | | DONG Yurong | Tianjin Medical University, Tianjin 300203, China | | | WANG Shuo | Tianjin Chest Hospital, Tianjin 300222, China
Tianjin Medical University, Tianjin 300203, China | wssean1609@163.com | | ZHAO Jia | Tianjin Chest Hospital, Tianjin 300222, China | orange2012@126.com |
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| Abstract
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| [Objective] The purpose of this study was to analyze the medication rules of traditional Chinese medicine compounds in the treatment of diabetes,and to clarify the mechanism of core traditional Chinese medicines in preventing and treating diabetes mellitus. [Methods] Data mining method was used for statistical analysis on the usage frequency,qi and flavor,meridian,and efficacy classification and correlation rule analysis of Chinese medicine prescriptions for treating diabetes mellitus on the patent network. Network pharmacology was used for the component targets of traditional Chinese medicine,construction of PPI network,drug-component-targeg-disease network,GO function annotation,KEGG function analysis. Molecular docking was used for the virtual verification of the drug and targets. [Results] The data mining results showed that Astragalus,Rehmannia,Dioscoreae Rhizoma,Pueraria lobata,Ophiopogon japonicus were used frequently. The proportion of mil-natured and cold drugs accounted for 46.52%,and the proportion of sweet and bitter flavors accounted for 64.09%. The association rules showed that astragalus-rehmannia glutinosa,astragalus-dioscoreae rhizoma, astragalus-pueraria lobata had higher confidence. The new high-frequency drug group was astragalus-pueraria lobata-ginseng. There were 57 common targets between drugs and diabetes mellitus. The GO function and KEGG enrichment pathway showed that inflammation may play an important role,and TNF signaling pathway may be an important pathway. Molecular docking results showed that AKT1,IL-6,and TNF may be the key targets for the drug group to prevent and treat diabetes mellitus. [Conclusion] The main medicines for the treatment of diabetes were to clear away heat and generate body fluid,and to replenish qi and nourish yin. The new drug group that was astragalus-pueraria lobata-ginseng may be affect the key targets which included AKT1,IL-6,TNF in the TNF signaling pathway to prevent and treat the diabetes mellitus. |
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