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| Clinical observation of Banxia Jiangni Decoction in the prevention and treatment of nausea and vomiting (spleen and stomach weakness) caused by cisplatin |
| Hits 569 Download times 777 Received:September 01, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.01.05 |
| Key Words
chemotherapy related nausea and vomiting;Banxia Jiangni Decoction;cisplatin;spleen and stomach weakness |
| Author Name | Affiliation | E-mail | | LI Dongdong | Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China | | | ZHANG Juan | Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China | | | ZHANG Xiaoqing | The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China | | | LIU Fangfang | Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China | | | LIU Peimin | Henan Province Hospital of Traditional Chinese Medicine, Zhengzhou 450002, China | zxq048@126.com |
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| Abstract
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| [Objective] To observe the effect of Banxia Jiangni Decoction on nausea and vomiting (spleen stomach weakness) caused by chemotherapy containing cisplatin (DDP) and its effect on the quality of life of patients.[Methods] 72 patients who were hospitalized in the oncology department of Henan Province Hospital of Traditional Chinese Medicine from April 2017 to December 2017 and were diagnosed as non-small cell lung cancer,esophageal cancer,cervical cancer and nasopharyngeal carcinoma by histopathology or (and) cytology. They met the diagnostic criteria of traditional Chinese and western medicine and needed DDP chemotherapy. They were randomly divided into control group (36 cases) and experimental group (36 cases),the control group used azasetron+dexamethasone to stop vomiting before DDP application,and the experimental group took Banxia Jiangni Decoction on the basis of the control group,8 days as a course of treatment. During the medication,the times of nausea and vomiting,the curative effect of traditional Chinese medicine syndrome,appetite,physical strength and safety indexes were observed,and the curative effect of Banxia Jiangni decoction was evaluated.[Results] Compared with the control group,the number of delayed nausea after chemotherapy in the experimental group was significantly reduced. The effective rate in the experimental group was 82.85% and that in the control group was 55.88%. There was significant difference between the two groups(P<0.05);compared with the control group,the times of delayed vomiting after chemotherapy in the experimental group were significantly reduced. The effective rate in the experimental group was 77.14% and that in the control group was 52.94%. There was significant difference between the two groups (P<0.05);there was no significant difference in acute nausea and vomiting between the two groups (P>0.05). There was significant difference between the two groups after treatment (P<0.05). After treatment,the appetite of the two groups decreased,and that of the control group decreased significantly. There was significant difference in the grade of appetite between the two groups (P<0.05). The physical strength of the two groups decreased significantly after treatment,and the physical strength of the control group decreased significantly. There was significant difference between the two groups by statistical analysis(P<0.01). In terms of safety,there was no significant adverse reaction between the two groups,and there was no difference by statistical analysis (P>0.05).[Conclusion] Banxia Jiangni Decoction can reduce delayed spleen and stomach weakness patients nausea and vomiting,improve traditional Chinese medicine syndrome,appetite and physical strength,which is safe and effective. |
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