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| Comparison of pharmacokinetic parameters of trans- and cis-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside on rats |
| Hits 578 Download times 852 Received:September 08, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.01.19 |
| Key Words
Polygonum multiflorum Thunb.;trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside;cis-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside;pharmacokinetics;single administration |
| Author Name | Affiliation | E-mail | | CHAI Shiwei | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300193, China | | | GAO Jian | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 301617, China | | | SHE Lihe | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 301617, China | | | YU Qiao | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 301617, China | | | PANG Xu | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 301617, China | | | HAN Lifeng | Key Laboratory of Traditional Chinese Medicinal Chemistry and Analytical Chemistry of Tianjin, Tianjin 301617, China | hanlifeng@tjutcm.edu.cn |
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| Abstract
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| [Objective] Comparison of the pharmacokinetic differences of trans-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (trans-TSG) and cis-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (cis-TSG) in Polygonum multiflorum Thunb. in rats.[Methods] After a single intragastric administration of 60 mg/kg of trans-TSG and cis-TSG,the drug concentrations in the plasma of rats were determined at different time points and the in vivo pharmacokinetic parameters were calculated.[Results] Significant differences were found in pharmacokinetic parameters. T1/2 of cis-TSG was significantly higher than that of trans-TSG(P<0.05). However,CLz/F,and Cmax of trans-TSG in the plasma were significantly higher than cis-TSG (P<0.05).[Conclusion] The pharmacokinetic behavior of trans-TSG and cis-TSG in rats was significantly different following a single intragastric administration of the same concentrations of them. |
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