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| Research progress on the mechanism of icariin on cardiovascular diseases |
| Hits 879 Download times 883 Received:September 18, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2023.01.22 |
| Key Words
icariin;cardiovascular disease;pharmacological action;mechanism of action;research progress |
| Author Name | Affiliation | E-mail | | LI Nan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | WANG Baohe | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | wbh3423@sina.com | | ZHANG Chen | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LIU Fanqi | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHANG Yao | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | SUN Yanjun | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | XU Cun | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Shuangqing | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Duojing | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | |
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| Abstract
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| Icariin is one of the main active ingredients of natural Chinese medicine epimedium. Several studies have shown that icariin has anti-vascular smooth muscle cell migration and proliferation,inhibition of inflammatory response,anti-oxidative stress response,anti-programmed cell death,inhibition of endothelial interstitialization,anti-pulmonary vascular remodelling,and anti-myocardial fibrosis can prevent cardiovascular diseases by regulating targets in multiple signal transduction pathways. In this paper,the mechanism of action of icariin in the prevention and treatment of cardiovascular diseases will be summarized to provide a reference for the development of new clinical drugs. |
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