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| Study on the distribution and evolution of traditional Chinese medicine syndromes in patients infected with the SARS-CoV-2 Omicron variant after nucleic acid turned negative |
| Hits 1131 Download times 1025 Received:November 10, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.02.02 |
| Key Words
Omicron variant;after nucleic acid turned negative;syndrome;evolution law;Qingjin Yiqi Granule |
| Author Name | Affiliation | E-mail | | JIANG Nan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | WANG Kai | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Xiaodan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LI Yadong | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHENG Wenke | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | TIAN Ying | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LIU Xiaomin | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | XUE Xiaoxue | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | NI Daoyan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHANG Shuo | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | ZHOU Shengyuan | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | FENG Jihong | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | | | LUO Mingchi | Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China | luomingchi2008@163.com |
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| Abstract
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| [Objective] To summarize the distribution and evolution of traditional Chinese medicine(TCM) syndromes in patients that were infected by the SARS-CoV-2 Omicron variant after nucleic acid turned negative.[Methods] The information of TCM clinical symptoms, tongue images,physical and chemical examinations of all 430 patients that were infected by the first round of SARS-CoV-2 Omicron epidemic in Tianjin were collected after nucleic acid turned negative. The frequency and ratio of clinical symptoms,tongue image factors,syndrome elements on the 1st,7th and 14th day of observations were counted,and the distribution characteristics and changes of syndromes were analyzed. The core syndromes of the patients after nucleic acid turned negative were summarized,and the effects of Qingjin Yiqi Granules treatment on the evolution of syndromes were observed.[Results] After the nucleic acid of the infected person turns negative,cough,pharyngeal discomfort,phlegm and other respiratory symptoms were still the most important and primary symptoms. By day 14,fatigue was the most frequent symptom,and more than 10% of patients still had respiratory and digestive symptoms. The most common syndrome elements after nucleic acid turned negative were spleen,lung,qi deficiency,heat,dampness,phlegm and yin deficiency. The common core syndromes of patients after nucleic acid turned negative are deficiency of both qi and yin,with phlegm dampness and heat stasis. Depending on the application of traditional Chinese medicine Qingjin Yiqi Granules,divided the patients into the treatment group(178 cases) and the non-treatment group(252 cases). Statistical analysis was made on the transformation of each syndrome element in the two groups,found that compared with the non-treatment group on the 7th day,the frequency of syndrome elements of the treatment group including spleen,lung,dampness,phlegm heat,yin deficiency,qi stagnation and blood deficiency decreased obviously. The differences were statistically significant (P＜0.05 or P＜0.01). On the 14th day,compared with the non-treatment group,the syndrome elements including spleen,lung,qi deficiency,heat,dampness,phlegm and yin deficiency in the treatment group were significantly decreased (P＜0.05 or P＜0.01).[Conclusion] Deficiency of both qi and yin,the remaining evil spirit has not been eliminated,which are the common core syndromes after nucleic acid turned negative of patients with SARS-CoV-2 Omicron infection. Qingjin Yiqi Granules can significantly improve the TCM syndromes of patients,and timely application after nucleic acid turned negative can promote the recovery of patients. |
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