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| Efficacy and safety of oral Chinese patent medicine in the treatment of lumbar disc herniation:a network Meta-analysis |
| Hits 2014 Download times 1141 Received:October 20, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.02.13 |
| Key Words
Chinese patent medicine;lumbar disc herniation;network Meta-analysis;Yaotongning Capsule;Yaobitong Capsule;Shujin Jianyao Pill;Biqi Capsule;Yaotui Tongning Capsule |
| Author Name | Affiliation | E-mail | | ZUO Yongli | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Regional traditional Chinese medicine Orthopedics Clinic Center of the State Administration of Traditional Chinese Medicine, National Research Center of Acupuncture and Moxibustion Clinical Medicine of Traditional Chinese Medicine, Tianjin 300193, China | | | WANG Ping | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Regional traditional Chinese medicine Orthopedics Clinic Center of the State Administration of Traditional Chinese Medicine, National Research Center of Acupuncture and Moxibustion Clinical Medicine of Traditional Chinese Medicine, Tianjin 300193, China | 2273042506@qq.com | | LENG Xiangyang | Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun 130021, China | | | ZHANG Juntao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Regional traditional Chinese medicine Orthopedics Clinic Center of the State Administration of Traditional Chinese Medicine, National Research Center of Acupuncture and Moxibustion Clinical Medicine of Traditional Chinese Medicine, Tianjin 300193, China | | | ZHANG Chao | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Regional traditional Chinese medicine Orthopedics Clinic Center of the State Administration of Traditional Chinese Medicine, National Research Center of Acupuncture and Moxibustion Clinical Medicine of Traditional Chinese Medicine, Tianjin 300193, China | | | FU Bifeng | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Regional traditional Chinese medicine Orthopedics Clinic Center of the State Administration of Traditional Chinese Medicine, National Research Center of Acupuncture and Moxibustion Clinical Medicine of Traditional Chinese Medicine, Tianjin 300193, China | |
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| Abstract
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| [Objective] To evaluate the efficacy and safety of different oral Chinese patent medicines on lumbar disc herniation (LDH) by means of network Meta-analysis and to provide evidence-based reference for clinical medication.[Methods] CNKI,Wanfang,VIP,China Biomedical Database,PubMed,Embase,Cochrane Library database were searched for clinical randomized controlled trials of oral Chinese patent medicines in the treatment of LDH from the establishment of the database to February 2022. The quality of the included RCTs was evaluated using the risk of bias assessment tool recommended by Cochrane,and RevMan5.4 and Stata15.1 were used to evaluate the efficacy and safety of oral Chinese patent medicine in the treatment of LDH.[Results] The 24 RCTs were included,involving a total of 6 proprietary Chinese medicines. The results of network Meta-analysis showed that the top three interventions in improving clinical efficacy were Biqi Capsules,Shujin Jianyao Pills and Yaobitong Capsules. In reducing VAS score,the top three interventions were Yaotui Tongning Capsules,Shujin Jianyao Pills and Yaotongning Capsules. In terms of drug safety,there were no serious adverse events in all studies,and most studies only reported mild gastrointestinal reactions of Chinese patent medicines.[Conclusion] Comprehensive comparison oral Chinese patent medicine can improve the clinical efficacy of lumbar disc herniation and has good safety,but limited by the quality and quantity of the included literature,the conclusion still needs more high-quality research to verify. |
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