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| Role of GPX4 in cardiovascular disease and research progress of traditional Chinese medicine intervention |
| Hits 1463 Download times 1395 Received:November 16, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2023.02.21 |
| Key Words
cardiovascular diseases;GPX4;traditional Chinese medicine;function;prescription |
| Author Name | Affiliation | E-mail | | YANG Xintong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yue | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Sixia | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LENG Ling | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, China | | | LI Ruiqiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, China | liruiqiao@tjutcm.edu.cn | | WANG Qilong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | wangqilong_00@tjutcm.edu.cn |
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| Abstract
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| Glutathione peroxidase 4(GPX4) is a crucial enzyme of the cellular antioxidant system and can inhibit intracellular lipid peroxidation and ferroptosis. Regulation of GPX4 activity has become therapeutically attractive,particularly in cardiovascular diseases such as atherosclerosis and myocardial ischemia-reperfusion. Traditional Chinese medicine(TCM) has apparent advantages in treating cardiovascular diseases. TCM-based mechanisms may be related to the regulation of GPX4 and inhibition of cellular oxidative stress,lipid peroxidation,and ferroptosis. In this review,GPX4 is used as an entry point to elucidate the role of GPX4 in cardiovascular diseases and to understand how TCM modulates GPX4 activity to prevent cardiovascular disease development or progression,so as to provide potential therapeutic targets for the treatment of cardiovascular diseases and drug development. |
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