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| Exploration of the relationship between iron metabolism disorder and myocardial ischemia-reperfusion injury from “qi-blood theory” |
| Hits 1378 Download times 1302 Received:November 12, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.02.22 |
| Key Words
theory of qi and blood;MI/R;ferroptosis;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | WANG Shuo | Tianjin Medical University, Tianjin 300070, China
Tianjin Chest Hospital, Tianjin 300222, China | | | SUN Xingyi | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DONG Yurong | Tianjin Medical University, Tianjin 300070, China | | | LIU Chang | Tianjin Medical University, Tianjin 300070, China | | | XIE Cun | Tianjin Chest Hospital, Tianjin 300222, China | | | ZHAO Jia | Tianjin Chest Hospital, Tianjin 300222, China | orange2012@126.com | | LI Chunjie | Tianjin Chest Hospital, Tianjin 300222, China | Lichunjie0227@126.com |
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| Abstract
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| Myocardial ischemia-reperfusion injury (MI/RI) is a kind of secondary heart injury,which is regarded as a mixture of deficiency and excess in traditional Chinese medicine (TCM) theory,and its occurrence and development are related to many pathological factors such as phlegm,blood stasis and qi deficiency. Ferroptosis is a form of iron-dependent cell death caused by iron metabolic disorder. Its mechanism mainly includes four pathways which are iron metabolism pathway,amino acid metabolism pathway,lipid metabolism pathway and ferritinophagy pathway. TCM is effective in regulating iron metabolism disorder in MI/RI. The method of supplementing qi and activating blood circulation,removing blood stasis and dredging collateral can reduce the accumulation of iron ions and the level of lipid peroxidation,and restore the balance of qi and blood in the body,thus alleviate myocardial ischemia. In this paper,the characteristics and mechanism of iron metabolism were summarized,the similarities between ferroptosis and qi-blood theory and the TCM methods are discussed in order to understand the mechanism of ferroptosis and the connotation of qi-blood theory. |
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