|
| Effect of Qingyi Decoction combined with ulinastatin on severe acute pancreatitis and its influence on immune function |
| Hits 503 Download times 723 Received:November 15, 2022 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2023.03.04 |
| Key Words
Qingyi Decoction|ulinastatin|inflammatory factor|severe acute pancreatitis|immunity |
| Author Name | Affiliation | E-mail | | CHEN Zilan | Department of Gestroenterology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215000, China | | | WU Suxiao | Department of Gestroenterology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Suzhou 215000, China | cissywu963@126.com |
|
| Abstract
|
| [Objective] To explore the curative effect of Qingyi Decoction combined with ulinastatin in the treatment of severe acute pancreatitis and its influence on the immune function of patients.[Methods] A total of 100 patients receiving severe acute pancreatitis treatment in our hospital from September 2020 to August 2021 were selected,the 100 patients were divided into control group and treatment group with 50 cases in each group by random number table method. The control group was treated with ulinastatin injection,and the treatment group was treated with Qingyi Decoction on the basis of the control group. The recovery of the two groups was compared,the score of traditional Chinese medicine(TCM) syndrome was detected,and the intestinal mucosal barrier function,pancreatic function,interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-α) was detect by enzyme-link immunosorbent assay Interleukin-8 (IL-8);the levels of immunoglobulin G (IgG),immunoglobulin A (IGA) and immunoglobulin M (IgM) was detect by immunoturbidimetry.[Results] After treatment,compared with the control group,the TCM syndrome score,D-lactate,diamine oxidase (DAO),glucagon (GLU),amylase (AMY),trypsinogen-2 (TPS-2),IL-6 and TNF-α in the treatment group was significantly higher,the levels of IL-8 is significantly lower (P<0.05);the levels of insulin (INS),IgG,IgA and IgM was significantly increase (P<0.05);the clinical effective rate of the treatment group was higher than that of the control group,with statistical difference (P<0.05).[Conclusion] Using Qingyi Decoction combined with ulinastatin in the treatment of severe acute pancreatitis,TCM syndrome score decreased,intestinal mucosal barrier function,pancreatic function and immune function were effectively improved,inflammatory response was reduced,and the overall treatment effect was significant. |
|
|
|
|
|
|
|
