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| Study on the therapeutic mechanism of Xiasangju Granule against hypertension based on GEO chip and network pharmacology |
| Hits 668 Download times 421 Received:January 03, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.03.17 |
| Key Words
Xiasangju Granule|hypertension|GEO chip|network pharmacology|molecular docking |
| Author Name | Affiliation | E-mail | | GAO Puxing | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | FU Qianfang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | LIU Yu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | RONG Ping | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | WANG Chuanfu | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | FENG Mingjia | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | | | WANG Qiang | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, 300381, China | Wqiang177@163.com |
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| Abstract
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| [Objective] To explore the therapeutic mechanism of Xiasangju Granules against hypertension based on GEO chip,network pharmacology,and molecular docking.[Methods] TCMSP database was used to obtain and screen the active components and component targets of Xiasangju Granules,and the "herb-compound-target" network was constructed. Using GEO chip technology,Genecards,OMIM, and TTD databases to obtain and screen the disease targets of hypertension. The intersection targets were taken and the "herb-compound-target" network was constructed. Take the intersection target of component target and disease target,construct PPI network,and screen the key target by secondary processing. Go and KEGG enrichment analysis of intersection targets. The first four positions of key targets and their corresponding active components were analyzed by molecular docking.[Results] The 194 component targets,2 168 disease targets,126 intersection targets,and 6 key targets were obtained. Go and KEGG enrichment analysis showed that Xiasangju Granules were mainly related to biological processes such as response to hormones,inorganic substances,nitrogen compounds,lipopolysaccharide,and extracellular stimulation. The main enrichment pathways involved signal pathways such as lipid and atherosclerosis,AGE-RAGE,PI3K-Akt,MAPK and TNF. The results of molecular docking showed that the key targets were well combined with the active components.[Conclusion] Xiasangju Granules can exert an effect through multi-component,multi-target,and multi-channel,which provides a reference for its clinical use in the prevention and treatment of hypertension. |
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