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| Efficacy of Xuefu Zhuyu Capsule combined with conventional Western medicine treatment for angina pectoris in coronary heart disease |
| Hits 779 Download times 801 Received:January 18, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.04.01 |
| Key Words
Xuefu Zhuyu Capsule;coronary heart disease and angina pectoris;blood pressure;carotid intima-media thickness |
| Author Name | Affiliation | E-mail | | TIAN Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Yijia | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Shuo | Tianjin Medical University, Tianjin 300070, China
Tianjin Chest Hospital, Tianjin 300222, China | | | ZHAO Jia | Tianjin Chest Hospital, Tianjin 300222, China | | | LI Lin | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Chunjie | Tianjin Chest Hospital, Tianjin 300222, China | Lichunjie0227@126.com | | YU Chunquan | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | ycq-4@163.com |
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| Abstract
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| [Objective] To investigate the effects of Xuefu Zhuyu Capsule on blood glucose, blood pressure and carotid intima-media thickness (CIMT) in patients with coronary heart disease and angina pectoris, and the relationship between blood pressure and CIMT. [Methods] The 474 patients with coronary heart disease and angina pectoris were selected and divided into treatment group and control group according to whether they took Xuefu Zhuyu Capsule. The difference of baseline data was adjusted through propensity score matching to study the difference of blood glucose, blood lipid, blood pressure and CIMT between the two groups. The association between blood pressure and CIMT was analyzed, and multiple linear regression analysis was performed with CIMT as the dependent variable, blood pressure classification as the independent variable, and sex, age, smoking, alcohol consumption, triglycerides(TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG) as covariates. [Results] There were significant differences in TG, TC, LDL-C, HbA1c, FPG, blood pressure and CIMT between the treatment group and control group (P<0.05). Compared with patients with normal blood pressure, hypertension was positively associated with CIMT(P<0.05). At the same time, there was a significant difference between hypertension grade 2 and CIMT (P<0.05). [Conclusion] Xuefu Zhuyu Capsule combined with conventional treatment of Western medicine can effectively reduce TG, TC, LDL-C, HbA1c, FPG, blood pressure and reduce CIMT in patients with angina pectoris of coronary heart disease, and hypertension is significantly associated with CIMT. |
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