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| Study on the cardiac protection of fecal extracts from Periplaneta americana L. in ex vivo rat hearts |
| Hits 690 Download times 808 Received:February 11, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.04.15 |
| Key Words
Periplaneta americana L.;fecal extract;ex vivo rat hearts;positive inotropic effect |
| Author Name | Affiliation | E-mail | | SHAN Luyu | Institute of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin key Laboratory of traditional Chinese medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Ziyan | Institute of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin key Laboratory of traditional Chinese medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Yaping | Institute of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin key Laboratory of traditional Chinese medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | WANG Qilong | Institute of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin key Laboratory of traditional Chinese medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CUI Ying | Institute of Traditional Chinese Medicine, State Key Laboratory of Component-based Chinese Medicine, Tianjin key Laboratory of traditional Chinese medicine Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | CQL8179270@tjutcm.edu.cn |
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| Abstract
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| [Objective] To investigate the cardiac protection of fecal extracts from Periplaneta americana L.(PAF) in ex vivo rat hearts. [Methods] The Langendorff perfusion model of ex vivo rat heart was established for monitoring the changes of the hemodynamic indexes caused by PAF administration, including the left ventricular systolic pressure(LVSP), left ventricular pressure maximum upstroke and decrease velocity (±dp/dtmax), and heart rate (HR). [Results] PAF could significantly enhance LVSP and ±dp/dtmax in ex vivo rat hearts, and was dose-dependent, of which 0.5 mg/mL had the most significant effect, but PAF had not shown a significant effect on HR. [Conclusion] In this study, PAF increased LVSP and ±dp/dtmax, which had a positive inotropic effect in ex vivo rat hearts and could enhance myocardial contractility. In addition, it showed no effect on heart rate, which was beneficial to reduce cardiac oxygen consumption and exert cardioprotection. |
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