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| Systematic evaluation and Meta analysis of modified Yiguanjian for treating chronic gastritis |
| Hits 559 Download times 1951 Received:January 23, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.05.14 |
| Key Words
Yiguanjian;chronic-gastritis;ranolomized controlled trial;Meta analysis |
| Author Name | Affiliation | | GONG Boyang | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | FAN Yadong | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | TIAN Zhikui | College of Health Science and Engineering of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | CUI Yan | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | WANG Ying | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | FAN Tianci | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | XU Zhe | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | BIAN Yuhong | School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China |
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| Abstract
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| [Objective] To systematically evaluate the clinical effect and safety of Yiguanjian in the treatment of chronic gastritis.[Methods] First, the Cochrane Library, Pubmed, China Journal Full text Database(CNKI), China Science and Technology Journal Full text Database (VIP), Wanfang Database, etc. were comprehensively searched to find out the randomized controlled trials of the treatment of chronic gastritis with Yiguanjian as of February 2022. The included literature was evaluated according to the Cochrane risk bias assessment tool, and quantitative synthesis was carried out with the Review Manager 5.4 software.[Results] Totally 1 357 patients were included in 13 studies, including 697 patients in the Yiguanjian group and 660 patients in the routine group. Meta analysis results showed that, compared with the conventional treatment scheme, the treatment of Yiguanjian could effectively improve the clinical efficacy of patients with chronic gastritis. The combined effect amount and 95% confidence interval of the total effective rate were [OR=4.86, 95%CI(3.39, 6.97), P < 0.000 01], and both were superior to the western medicine group and the Chinese patent medicine group. In addition, compared with the conventional treatment group, the improved rate of gastroscopy was significantly increased by the addition and subtraction of Yiguanjian [OR=3.43, 95%CI (1.47, 8.01), P < 0.000 01];improve the negative rate of HP [OR=17.07, 95%CI(6.62, 44.04), P < 0.000 01)]; improve the serum PGI of pepsin[MD=12.05, 95%CI(8.25, 15.84), P < 0.000 01];reduce the incidence of adverse reactions.[Conclusion] According to the existing research data, the clinical efficacy and safety of Yiguanjian in the treatment of chronic gastritis are better than those of the conventional treatment group, and it can improve the improvement rate of gastroscope, turn negative rate of HP and reduce the level of serum PGI of pepsin. However, due to the low quality of the included literature, the conclusion needs more high-quality research to verify. |
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