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| Clinical effect of Ziyu Ointment combined with Xileisan in the treatment of ulcerative proctitis with heat toxin burning syndrome |
| Hits 541 Download times 1557 Received:December 28, 2022 |
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| DOI
10.11656/j.issn.1672-1519.2023.06.05 |
| Key Words
Ziyu Ointment;Xileisan;rectal administration;mesalazine suppository;ulcerative proctitis |
| Author Name | Affiliation | E-mail | | LIU Xiaoyi | Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | CHEN Aixia | Second Department of Anorectal Surgery, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China | 1058342047@qq.com | | CHEN Shanhu | Second Department of Anorectal Surgery, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China | | | ZHANG Xiaoyu | Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | PENG Hong | Department of Nursing, First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China | |
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| Abstract
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| [Objective] To observe the clinical efficacy of Ziyu ointment combined with Xileisan rectal administration in the treatment of ulcerative proctitis with hot toxin burning syndrome. [Methods] Sixty patients with ulcerative proctitis were randomly divided into control group and treatment group according to outpatient order，with 30 cases in each group. The treatment group was given Ziyu Ointment combined with Xileisan for rectal administration，while the control group was given mesalazine suppository for anal treatment，with a course of 4 weeks. The clinical efficacy，clinical symptom score，inflammatory index，proctoscopy score and adverse drug reactions of the two groups were observed before and after treatment. [Results] After treatment，the total effective rate was 93.33% in the treatment group and 96.67% in the control group. There was no significant difference in the total effective rate between the two groups（P>0.05）. The clinical symptom score，inflammatory index （TNF-α，IL-8，IL-10） and rectal examination score in the treatment group were statistically different from those before treatment（P<0.01），while there was no statistical difference compared with the control group（P>0.05），but the incidence of adverse reactions was lower （P<0.05）. [Conclusion] Rectal administration of Ziyu Ointment combined with Xileisan had similar efficacy in the treatment of ulcerative proctitis as compared with mesalazine suppository，and both of them could effectively improve clinical symptoms and reduce inflammatory reaction. However，the incidence of adverse reactions of Ziyu Ointment combined with Xileisan was lower，so it was worthy of clinical application. |
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