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| Clinical effect and related mechanism of Yishen Tongdu Formula on ankylosing spondylitis |
| Hits 1180 Download times 547 Received:February 18, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.07.02 |
| Key Words
ankylosing spondylitis;kidney deficiency and dampness-heat;traditional Chinese medicine;Yishen Tongdu Formula |
| Author Name | Affiliation | E-mail | | ZHANG Shuo | Department of Rheumatology, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China | | | WEN Bo | Department of Rheumatology, Beijing Hospital of Traditional Chinese Medicine, Beijing 100010, China | | | YANG Ruishan | Department of Heart Function, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China | jcwlyrs@163.com。 |
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| Abstract
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| [Objective] To investigate the therapeutic effect of Yishen Tongdu Formula on ankylosing spondylitis（AS） and to analyze its therapeutic mechanism. [Methods] The 82 AS patients admitted to our hospital from January 2019 to December 2021 were selected and divided into treatment group and control group according to the random number table method，with 41 cases in each group. The control group were given celecoxib capsules，while the treatment group were given Yishen Tongdu Formula，a traditional Chinese medicine（TCM），the treatment was for 12 weeks. Spinal pain score，night pain score，Bath ankylosing spondylitis Activity index （BASDAI），Bath ankylosing spondylitis Function index （BASFI），finger ground distance，occipital wall distance，thoracic motion，Schober test and TCM syndrome score were compared between the two groups before and after treatment. Efficacy was evaluated with the protocol recommended by the International Working Group on the International AS Scoring Working Group （ASAS）. Erythrocyte sedimentation rate （ESR），serum C-reactive protein （CRP），tumor necrosis factor-α （TNF-α），interleukin-17 （IL-17），and soluble leukocyte associated immunoglobulin like receptor-1 （AIR-1） levels were compared between the two groups before and after treatment. The relative expression levels of miR-155 and miR-223 in peripheral blood mononuclear cells （PBMC） were compared between the two groups. [Results] BASDAI，BASFI，spinal pain score，nocturnal pain score，digital ground distance，occipital wall distance，TCM syndrome score of the treatment group were lower than those of the control group （P<0.01）；thoracic motion and Schober test were higher than that of the control group （P<0.01），ASAS 20，ASAS 40，ASAS 5/6 and BASDAI 50 of treatment groups were higher than those of the control group （P<0.05）；the levels of ESR，serum CRP，TNF-α，IL-17 and AIR-1，and the relative expression levels of miR-155 and miR-223 of PBMC were lower than those of the control group （P<0.01）. [Conclusion] Yishen Tongdu Formula can reduce the secretion of inflammatory factors，slow down the progression of inflammation，improve symptoms and signs and TCM syndrome scores，and it is effective and safe in the treatment of AS. The mechanism may be related to regulating the expression of serum LAIR-1，PBMC miR-155，and miR-223. |
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