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| Discussion of the essence of treating metabolism-related fatty liver disease from phlegm and dampness from the perspective of intestinal flora and inflammation |
| Hits 514 Download times 367 Received:April 28, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.07.06 |
| Key Words
gastrointestinal microbiome;metabolism-related fatty liver disease;fatty liver;inflammation;phlegm-damp |
| Author Name | Affiliation | E-mail | | ZHANG Yanjie | Beijing University of Chinese Medicine, Beijing 100029, China
Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical university, Beijing 100010, China | | | DU Hongbo | Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China | | | LI Xiaoling | Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical university, Beijing 100010, China | | | ZHANG Yingxue | Beijing University of Chinese Medicine, Beijing 100029, China | | | SUN Fengxia | Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical university, Beijing 100010, China | sunfengxia01969@163.com。 |
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| Abstract
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| Metabolic associated fatty liver disease（MAFLD） is a heterogeneous disease with multiple pathogenesis interactions. There is currently no recognized effective therapeutic drug，and traditional Chinese medicine treatment has shown superiority in the treatment of this disease with its multi-target advantages. Sputum wetness is the commonly recognized pathogenesis of MAFLD at present，but the specific mechanism has not been fully elucidated. Modern studies have shown that intestinal microbiota disorders can promote the occurrence of MAFLD，and inflammation is the only way for intestinal microbiota disorders to trigger the pathogenesis of MAFLD. In this paper，by elaborating the correlation between the etiology，constitution and intestinal flora disorder of MAFLD sputum dampness，and linking the characteristics of sputum wetness with the pathogenic characteristics of chronic inflammation and the evolution of MAFLD. This paper proposes that intestinal microbiota disorder is the material basis for the production of sputum dampness in MAFLD，and chronic inflammation is the essence of sputum dampness. On this basis，it is proposed that the treatment of MAFLD from phlegm and wetness should emphasize strengthening the spleen and regulating qi and blood，and its mechanism of action is related to the regulation of inflammation and intestinal flora. |
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