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| Meta-analysis of the effect of salvia miltiorrhiza polyphenolate injection on the incidence of mace events and vascular endothelial function after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) |
| Hits 440 Download times 319 Received:April 20, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.07.12 |
| Key Words
salvianolate;acute coronary syndrome;after percutaneus coronary intervention;vascular endothelial function;Meta-analysis;GRADE evaluation |
| Author Name | Affiliation | E-mail | | XU Yazhou | Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | YAN Haifeng | Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | YU Rui | Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | LI Bin | Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | | | BAO Yu | The First Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou 450000, China | | | ZHU Mingjun | Heart Center, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China | zhumingjun317@163.com。 |
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| Abstract
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| [Objective] To evaluate the effects of salvia miltiorrhiza polyphenolate injection on mace events and vascular endothelial function after percutaneous coronary intervention （PCI） in patients with acute coronary syndrome （ACS）. [Methods] The computer searches PubMed，the Cochrane Library，web of science，CNKI，Wanfang Data and VIP databases. Randomized controlled trial of salvia miltiorrhiza polyphenolate injection in the treatment of acute coronary syndrome after PCI was collected. The retrieval time was from the establishment of the database to June 2022. After two researchers independently screened the literature，extracted data and evaluated the risk of bias included in the study，Revman 5.3 software was used for meta-analysis. [Results] A total of 16 RCTs were included，including 1 843 patients. Meta-analysis showed that compared with conventional Western medicine，salvia miltiorrhiza polyphenolate injection combined with conventional Western medicine could reduce the incidence of major cardiovascular adverse events （MACE） after PCI in patients with ACS[RR=0.35，95%CI（0.24，0.51），P<0.000 01]. Decrease the levels of endothelin-1 （ET-1）[SMD=-1.57，95%CI（-2.10，-1.04），P<0.000 01]，malondialdehyde （MDA） [MD=-1.98，95%CI（-2.09，-1.88），P<0.000 01]，high-sensitivity C-reactive protein （hs-CRP）[SMD=-1.76，95%CI（-2.19，-1.33），P<0.000 01] and C-reactive protein （CRP）[SMD=-1.25，95%CI（-1.64，-0.87），P<0.000 01]；Increase the level of vascular endothelial nitric oxide （NO）[SMD=1.34，95%CI（0.97，1.72），P<0.000 01]，superoxide dismutase （SOD） [MD=51.74，95%CI（49.04，54.44），P<0.000 01] and left ventricular ejection fraction （LVEF） [MD=7.22，95%CI（6.27，8.16），P<0.000 01]. [Conclusion] Salvia miltiorrhiza polyphenolate injection combined with conventional Western medicine can reduce the incidence of mace events after PCI for acute coronary syndrome and improve vascular endothelial function and left ventricular ejection fraction. Limited by the number and quality of included studies，the above conclusions need to be verified by more high-quality studies. |
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