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Mechanism of microglia-astrocyte crosstalk in neuropathic pain and the research progress on traditional Chinese medicine
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DOI   10.11656/j.issn.1672-1519.2023.07.21
Key Words   neuropathic pain;astrocytes;microglia;crosstalk;traditional Chinese medicine
Author NameAffiliationE-mail
CHEN Yuzhao State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China 		 
WU Meirong State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 		 
ZHANG Han State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 		 
LI Lin State Key Laboratory of Components of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China 		 
ZHANG Lei First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China 		zhangleitj2008@163.com。 
Abstract
    Neuropathic pain is a chronic pain state caused by peripheral and/or central nerve injury. Neuroinflammation mediated by microglia and astrocytes whitch play an important role in the generation and maintenance of chronic pain. Microglia participate in the production of astrocyte pro-inflammatory mediators，and astrocytes take part the secretion of microglial inflammatory factors，inducing them to produce pro-inflammatory effects，their crosstalk can significantly affect the development of neuroinflammation. This article summarized the role of microglia-astrocyte crosstalk in neuropathic pain and the research status of traditional Chinese medicine by reviewing and studying relevant literature，in order to provide new target for the mechanism and treatment of neuropathic pain.

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