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| To explore the effect and related mechanism of Jianwei Xiaowei Decoction in the treatment of chronic atrophic gastritis |
| Hits 417 Download times 302 Received:April 21, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.08.03 |
| Key Words
chronic atrophic gastritis;traditional Chinese medicine;Jianwei Xiaowei Decoction;pepsinogen;Janus kinase 2;signal transducers and activators of transcription 3 |
| Author Name | Affiliation | E-mail | | HUANG Yuping | Department of Gastroenterology, The Second People's Hospital of Nantong, Nantong 226002, China | | | DING Jiangtao | Department of Gastroenterology, The Second People's Hospital of Nantong, Nantong 226002, China | hyphyx18994108261@163.com |
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| Abstract
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| [Objective] To investigate the effect of Jianwei Xiaowei Decoction in the treatment of chronic atrophic gastritis (CAG),and analyze its therapeutic mechanism preliminarily. [Methods] The 103 CAG patients admitted to our hospital from March,2021 to September,2022 were selected and divided into observation group(51 cases) and control group(52 cases) according to the random number table method. Finally,48 cases were included in each group. The control group were treated with omeprazole enteric-coated capsules and Rebamipide tablets,and the observation group were treated with Chinese medicine Jianwei Xiaowei Decoction on the basis of the treatment of the control group. The course of treatment was for 12 weeks. The traditional Chinese medicine(TCM) syndrome score and gastric mucosal pathological score were compared between the two groups before and after treatment. The serum levels of pepsinogen (PG) Ⅰ,PGⅡ and gastrin-17 (G-17) were compared between the two groups,and the PGⅠ/PGⅡ ratio (PGR) was calculated. The relative expression levels of Janus kinase 2 (JAK2) mRNA and signal transducer and activator of transcription 3 (sSTAT3) mRNA in peripheral blood mononuclear cells (PBMCs) were compared between the two groups,and the total effective rate of the two groups was compared. [Results] After treatment,the TCM syndrome score and gastric mucosal pathological score of the observation group were lower than those of the control group (P<0.01). The serum levels of PGⅠ,G-17 and PGR of the observation group were higher than those of the control group(P<0.01),and the serum level of PGⅡ was lower than that of the control group(P<0.01). The relative expression of JAK2mRNA and STAT3 mRNA in PBMCs were lower than that of the control group(P<0.01). The total effective rate of the treatment group was higher than that of the control group (P<0.05). [Conclusion] Jianwei Xiaowei Decoction can improve the TCM syndrome and pathological state of gastric mucosa in patients with CAG,regulate the secretion of PG,and improve the clinical effect of CAG. The mechanism may be related to the inhibition of JAK2/STAT3 expression. |
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