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| Clinical effect of Maiguan Fukang Tablets in treatment of lower extremity arteriosclerosis obliterans：a Meta analysis |
| Hits 333 Download times 285 Received:June 17, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.10.14 |
| Key Words
Maiguan Fukang Tablet;lower extremity arteriosclerosis obliterans;randomized controlled trial;Metaanalysis |
| Author Name | Affiliation | | LIU Yushan | School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China | | GUO Chunyue | Research Center, The Third Central Hospital of Tianjin, Hedong District, Tianjin 300170, China | | LIU Meng | Department of Vascular & Endovascular Surgery, The Third Central Hospital of Tianjin, Hedong District, Tianjin 300170, China |
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| Abstract
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| [Objective] To systematically review the clinical efficacy of Maiguan Fukang Tablet on patients with lower extremity arteriosclerosis obliterans. [Methods] PubMed，EMbase，The Cochrane Library，Web of Science，Scopus，CNKI，Wanfang data，VIP，CBM databases were electronically searched to collect randomized controlled trials （RCTs） on the clinical efficacy of Maiguan Fukang Tablets for lower extremity arteriosclerosis obliterans from inception to January 31st，2023. Two reviewers independently screened literature，extracted data and assessed the risk of bias in included studies，and then meta-analysis was performed by using RevMan 5.4 software. [Results] A total of 11 RCTs involving 809 patients were included. The results of meta-analysis showed that the Maiguan Fukang Tablets group exhibited an increased efficacy rate [RR=1.16，95%CI 1.02 to 1.32，P=0.03] and a decreased rate of intermittent claudication [RR=0.36，95%CI 0.23 to 0.58，P＜0.000 1]，rest pain [RR=0.28，95%CI 0.12 to 0.66，P=0.004] and amputation [RR=0.32， 95%CI 0.13 to 0.78，P=0.01]. Compared with the control group，the Maiguan Fukang Tablets significantly improved the ankle brachial index [SMD=0.13，95%CI （0.11，0.15），P＜0.000 1] and reduced the high shear viscosity level [SMD=-0.89，95%CI （-1.46，-0.31），P=0.0030]，whereas no statistically significant difference was found for the low shear viscosity level [SMD=-1.34，95%CI （-3.43，0.74），P=0.2100]. [Conclusion] Current evidence suggests that Maiguan Fukang Tablets can significantly improve intermittent claudication，rest pain and amputation，increase the ankle brachial index，and decrease the high shear viscosity level. Due to the limited quantity and quality of included studies，more high-quality studies are required to verify above conclusions. |
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