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| Clinical analysis of Huazhuo Jiedu Recipe combined with Western medicine in the treatment of acute gouty arthritis turbidity toxin intrinsic type |
| Hits 527 Download times 469 Received:August 23, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.11.04 |
| Key Words
Huazhuo Jiedu Recipe;acute gouty arthritis;blood uric acid;traditional Chinese medicine syndrome score;bone destruction |
| Author Name | Affiliation | E-mail | | DAI Jinying | Tangshan Traditional Chinese Medicine Hospital, Tangshan 063000, China | | | WANG Xu | The Second Hospital of Tangshan, Tangshan 063000, China | | | LIU Zhengang | The Second Hospital of Tangshan, Tangshan 063000, China | | | WANG Hao | Tangshan Traditional Chinese Medicine Hospital, Tangshan 063000, China | | | WANG Shunyi | Tangshan Traditional Chinese Medicine Hospital, Tangshan 063000, China | | | ZHANG Jun | Tangshan Traditional Chinese Medicine Hospital, Tangshan 063000, China | tszhangj0@126.com |
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| Abstract
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| [Objective] To explore the clinical effect of Huazhuo Jiedu Recipe combined with Western medicine on acute gouty arthritis(AGA) with turbidity toxin intrinsic type. [Methods] A total of 118 AGA patients with turbidity toxin intrinsic type in Tangshan Traditional Chinese Medicine Hospital from December 2020 to December 2022 were selected and they were divided into observation group and control group according to random number table method, with 59 cases respectively. The control group was treated with conventional Western medicine, and the observation group was treated with Huazhuo Jiedu Recipe on the basis of the control group. Both groups were treated for 2 weeks. The curative effect, traditional Chinese medicine syndrome score, blood uric acid level, inflammation [interleukin-1β(IL-1β), cysteinase-1(Caspase-1), Nod-like receptor heat protein domain 3(NLRP3)], bone destruction index [hypoxia-inducible factor-1α(HIF-1α), resistin(RETN), leptin(LEP)], adverse reactions were compared. [Results] The total effective rate of the observation group of 98.31% was higher than that of 86.44% in the control group(P<0.05). After treatment, TCM syndrome score and blood uric acid level were significantly decreased, and observation group was significantly lower than control group(P<0.05). After treatment, serum levels of IL-1β, Caspase-1, NLRP3, HIF-1α, RETN and LEP were significantly decreased, and observation group was significantly lower than control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). [Conclusion] Huazhuo Jiedu Recipe combined with Western medicine in the treatment of AGA turbidity toxin intrinsic type has remarkable effect, and it can effectively improve symptoms, reduce inflammation and bone damage, and it has high safety. |
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