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| Clinical efficacy and related mechanism of Liangxue Huayu Formula in the treatment of diabetic retinopathy |
| Hits 435 Download times 468 Received:July 20, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.11.06 |
| Key Words
Liangxue Huayu Formula;diabetic retinopathy;clinical efficacy;related mechanism |
| Author Name | Affiliation | E-mail | | DU Rui | Xi'an No. 1 Hospital, Xi'an 710000, China | | | XING Minyan | Xi'an No. 1 Hospital, Xi'an 710000, China | 114697480@qq.com |
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| Abstract
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| [Objective] To explore and analyze the clinical effect and related mechanism of Liangxue Huayu Formula in treating diabetic retinopathy(DR) with blood-heat stasis. [Methods] The 89 patients with DR in our hospital from March 2019 to March 2020 were selected and randomly divided into observation group(45 cases) and control group(44 cases) according to the random number table method. The control group was given calcium dobesilate capsules on the basis of conventional treatment, and the observation group was given Liangxue Huayu Formula on the basis of the control group. Both groups were treated for 3 months. The clinical efficacy, changes of retinal hemodynamics, eye related indexes, oxidative stress and serum inflammatory factors were compared between the two groups. [Results] The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the EDV, PSV and Vm of the two groups were significantly higher than before treatment(P<0.05). After treatment, the CRV, RI and PI of the two groups were significantly lower than before treatment(P<0.05), and the observation group was EDV, PSV and Vm were significantly higher than the control group(P<0.05), and CRV, RI and PI were significantly lower than the control group(P<0.05). After treatment, the visual field gray value, macular thickness, bleeding spot area, and hemangioma volume of the two groups of patients were significantly lower than before treatment(P<0.05). After treatment, the visual field gray value, macular thickness, bleeding spot area, and hemangiomas of the observation group were significantly reduced. The volume of hemangioma was significantly lower than that of the control group(P<0.05). After treatment, the serum Chemerin, MCP-1 and MDA of the two groups were significantly lower than those before treatment(P<0.05), and the serum SOD was significantly higher than that before treatment(P<0.05). After treatment, the serum Chemerin, MCP-1 and MDA of the observation group were significantly lower than those of the control group(P<0.05), and the serum SOD was significantly higher than that of the control group(P<0.05). [Conclusion] The treatment of diabetic retinopathy with cooling blood and removing stasis can effectively improve the clinical curative effect and promote the improvement of ocular symptoms. The mechanism may be related to the improvement of local microcirculation and the reduction of retinal oxidative stress and inflammatory injury, which is worthy of clinical promotion. |
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