|
| Mechanism research of Baoshen Tongluo Formula inhibition on inflammation and extracellular matrix accumulation of glomeruli to reduce kidney demage in DN mice |
| Hits 548 Download times 549 Received:July 15, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2023.11.16 |
| Key Words
Baoshen Tongluo Formula;diabetic nephropathy;mesangial matrix;Collagen Ⅳ;fibronectin;inflammation |
| Author Name | Affiliation | E-mail | | CUI Fangqiang | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | WANG Yuefen | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | CAI Zhen | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | MENG Yuan | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | JIANG Xincan | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | | | ZHAO Wenjing | Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China | wenjingz@263.net |
|
| Abstract
|
| [Objective] To observe the effect of Baoshen Tongluo Formula(BSF) on inflammation and extracellular matrix accumulation of glomeruli in DN mice. [Methods] The model KK-Ay mice were separated into 3 groups randomly, DN group, XST group and BSF group. Ten C57 mice performed for NC group. Mice in BSF group were given BSF. Mice in XST group were given XST. Mice in DN and NC group were given distilled water. All mice were successive administration for 12 weeks. [Results] Compared with NC group, 24 h proteinuria, serum creatinine and urea nitrogen was significantly increased(P<0.05) and mesangial matrix was significantly accumulated in DN group. Compared with NC group, Collagen Ⅳ and FN expression was significantly increased in DN group(P<0.05). IL-6 and TNF-α was significantly increased in DN group(P<0.05). Compared with DN group, 24 h proteinuria, serum creatinine and urea nitrogen was significantly decreased(P<0.05) and mesangial matrix accumulation was significantly reversed in BSF group and XST group. Compared with DN group, Collagen Ⅳ and FN expression was significantly decreased in BSF group and XST group(P<0.05). IL-6 and TNF-α was significantly decreased in BSF group and XST group(P<0.05). [Conclusion] BSF can alleviate proteinuria and ameliorate renal function of DN, which partially through decreasing extracellular matrix accumulation and inflammation in DN. |
|
|
|
|
|
|
|
