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| Effects of Shugan Zishen Formula on sex hormone levels and IVF-ET treatment outcomes in patients with decreased ovarian reserve function of liver and kidney deficiency type |
| Hits 652 Download times 326 Received:August 26, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.12.02 |
| Key Words
Shugan Zishen Formula;decreased ovarian reserve function;ovarian microenvironment;ovarian reserve function;outcome of IVF-ET treatment |
| Author Name | Affiliation | E-mail | | KANG Hua | Department of Reproductive Medicine, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | HAO Meijuan | Department of Reproductive Medicine, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | eiki37@163.com | | GUO Lishang | Department of Reproductive Medicine, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | WANG Xuchu | Department of Reproductive Medicine, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | | | MA Jianxin | Department of Reproductive Medicine, Cangzhou Hospital of Integrated Traditional and Western Medicine, Cangzhou 061000, China | |
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| Abstract
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| [Objective] To investigate the effects of Shugan Zishen Formula on sex hormone levels and IVF-ET treatment outcomes in patients with decreased ovarian reserve function of liver and kidney deficiency type. [Methods] A total of 98 patients with decreased ovarian reserve function were selected from the hospital and enrolled from November 2020 to November 2021. The grouping method was random number table method. The 49 patients were in the Western medicine group and received IVF-ET treatment,while 49 patients were in the Shugan Zishen Formula group and were treated with Shugan Zishen Formula on the basis of the Western medicine group. Sex hormone levels [follicle-stimulating hormone(FSH),luteinizing hormone(LH)],growth differentiation factor-9(GDF-9),anti-Muller's tube hormone(AMH) and Toll-like receptor 2(TLR2) before and after treatment were compared between the two groups. Ovarian status [peak systolic flow rate of ovarian artery(PSV),number of follicles in ovarian sinus(AFC)];traditional Chinese medicine(TCM) syndrome score before and after treatment;The dosage of gonadotropin(Gn),egg rate of MII,number of harvested follicles,fertilization rate,clinical pregnancy rate,abortion rate and adverse reactions were recorded in the two groups. [Results] After treatment,the contents of LH and FSH in Shugan Zishen Formula group were significantly lower than those in Western medicine group,and the contents of AMH were significantly higher than those in Western medicine group,with statistical significance(P＜0.05). The TLR2 content of Shugan Zishen Formula group was significantly lower than that of Western medicine group,and GDF-9 level was significantly higher than that of Western medicine group,with statistical significance(P＜0.05). PSV and AFC in Shugan Zishen Formula group were significantly higher than those in Western medicine group,and the difference was statistically significant(P＜0.05). The TCM syndrome score of Shugan Zishen Formula group was significantly lower than that of Western medicine group,and the difference was statistically significant(P＜0.05). The dose of Gn used in Shugan Zishen Formula group was lower than that in western medicine group,and the number of follicles obtained was more than that in western medicine group,with statistical significance(P＜0.05);the fertilization rate,MII egg rate and clinical pregnancy rate in Shugan Zishen Formula group were higher than those in Western medicine group,with statistical significance(P＜0.05);there was no statistical significance in abortion rate between the two groups(P＜0.05). There was no obvious adverse reaction in both groups during treatment. [Conclusion] In the treatment of patients with decreased ovarian reserve function of liver and kidney deficiency type,Shugan Zishen Formula can adjust sex hormone levels,inhibit body inflammation,improve ovarian microenvironment,enhance ovarian reserve function,relieve clinical symptoms,reduce the dosage of Gn,increase fertilization rate,MII egg rate and clinical pregnancy rate,and improve the outcome of IVF-ET treatment. |
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