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| Efficacy and safety of treatment of children with Tourette’s syndrome by traditional Chinese medicine:a systematic review and Meta-analysis |
| Hits 650 Download times 340 Received:September 28, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2023.12.12 |
| Key Words
children with Tourette's syndrome;systematic review;Meta-analysis |
| Author Name | Affiliation | E-mail | | WU Shangbin | Department of Pediatrics, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, China | | | WANG Keyi | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIN Xiaohong | Department of Pediatrics, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, China | | | WANG Hui | Evidence-based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wanghuiebm@126.com | | DU Shujuan | Department of Pediatrics, Guangdong Hospital of Traditional Chinese Medicine, Guangzhou 510120, China | cdsj2000@163.com |
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| Abstract
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| [Objective] To systematically evaluate the efficacy and safety of treatment of children with Tourette's syndrome by traditional Chinese medicine. [Methods] 6 databases of China National Knowledge Infrastructure(CNKI),Wanfang Data,SinoMed,PubMed,the Cochrane Library and Embase were comprehensively searched by computer to collect randomized controlled trials of treatment of children with Tourette's syndrome by traditional Chinese medicine. The retrieval time was from these databases inception to April 30,2022.RevMan 5.4.1 software was used for data analysis after independent literature screening,data extraction,and bias risk assessment according to pre-established inclusion and exclusion criterias. [Results] Finally,16 RCTs with 1 371 patients were included. Metaanalysis showed that traditional Chinese medicine in the treatment of pediatric tics can improve clinical efficacy, [OR =2.22,95% CI(1.58,3.13),P＜0.01],improved the YGTSS total score[MD=-3.70,95%CI(-4.99,-2.42),P＜0.01],YGTSS motor tic activity score[MD=-2.50,95%CI(-3.19,-1.81),P＜0.01],YGTSS vocal tic score[MD=-1.56,95%CI(-2.38,-0.75),P＜0.01],reduce the TSSS score[MD=0.08,95%CI(0.03,0.13),P＜0.01],improve the ISLQ score[MD=5.30,95%CI(0.33,10.27),P＜0.01],reduce the score of traditional Chinese medicine syndrome,and have good safety[OR=0.17,95%CI(0.09,0.31),P＜0.01]. [Conclusion] Traditional Chinese medicine in the treatment of Tourette's syndrome in children can improve clinical efficacy,improve motor tic and vocal tic symptoms,improve children's quality of life,reduce traditional Chinese medicine syndrome score. And it has good clinical safety. Due to the limitation of the quality of the included ariticles,high-quality clinical studies are needed for validation the conclusion. |
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