|
| A randomized controlled study:Qingying Powder in improving depression,anxiety and antibody disorder in patients with hashimoto thyroiditis complicated with subclinical hypothyroidism |
| Hits 585 Download times 362 Received:September 20, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.01.06 |
| Key Words
hashimoto thyroiditis;subclinical hypothyroidism;Qingying Powder;anti-thyroid peroxidase antibody;anti-thyroglobulin body antibody;depression self-rating scale;anxiety self-rating scale;quality of life rating scale SF-36 |
| Author Name | Affiliation | E-mail | | CHEN Yi | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | LI Sisi | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | WANG Wenyan | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | GAO Wenlan | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | WANG Xuefei | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | LIU Zhenxiu | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | LI Qingchun | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | | | TAO Feng | Department of Endocrinology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China | taofeng@shutcm.edu.cn |
|
| Abstract
|
| [Objective] To observe the effect of Qingying Powder on depression and anxiety in patients with hashimoto thyroiditis of liver depression and spleen deficiency complicated with subclinical hypothyroidism and its effect on serum anti-thyroid peroxidase antibody and anti-thyroglobulin antibody. [Methods] Using a prospective design,154 patients with hepatopathy and spleen deficiency type hashimoto thyroiditis(HT) combined with subclinical hypothyroidism(SCH) were specifically diagnosed between July 2021 and June 2022 at the thyroid specialty clinic of Shanghai Municipal Hospital of Traditional Chinese Medicine. They were divided into two groups according to different treatment regimens using a random number table,with experimental group treated with debridement gall dispersion combined with yumelen(77 cases) and control group treated with single agent yumelen(77 cases) for 12 weeks. The depression and anxiety self rating scale(SDS,SAS) scores,the quality of life in thyroid disease(SF-36) scores,and the serum concentrations of antithyroid peroxidase antibody (TPOAb),antithyroglobulin antibody(TGAb),and thyrotropin(TSH) in the two groups before and after treatment were observed. [Results] After 12 weeks of treatment,the SDS and SAS scores of the experimental group decreased significantly more than those of the control group than those of the control group(P＜0.01),and the SF-36 scores of the experimental group increased significantly than those of the control group,compared with those of the control group(P＜0.05). Serum TPOAb and TGAb in the experimental group decreased significantly compared to pretreatment values(P＜0.01),and no significant changes were observed in the control group before and after treatment;serum TSH decreased significantly after treatment in both groups compared to before(P＜0.01).The overall response rate of the experimental group was 86.4%,significantly higher than that of the control group by 42.6%,with a significant difference between the two groups(P＜0.01). [Conclusion] The treatment of 12 weeks with Qingying Powder plus low-dose Eugenol significantly improved depression and anxiety,quality of life,and reduced serum TSH,TPOAb,and TgAb levels in patients with HT combined with SCH with liver depression and spleen deficiency. |
|
|
|
|
|
|
|
