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To explore the theoretical framework of Zizao Yangrong Decoction in improving EGFRIs-related xerosis based on “endogenous dryness injuries yin
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DOI   10.11656/j.issn.1672-1519.2024.01.12
Key Words   Zizao Yangrong Decoction;EGFRIs;xerosis;endogenous dryness;theory of traditional Chinese medicine
Author NameAffiliationE-mail
ZHENG Yumin Beijing University of Chinese Medicine, Beijing 100029, China
Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China 
 
ZHANG Xu Beijing University of Chinese Medicine, Beijing 100029, China
Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China 
 
YU Yixuan Beijing University of Chinese Medicine, Beijing 100029, China
Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China 
 
LU Xinyu Beijing University of Chinese Medicine, Beijing 100029, China
Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China 
 
DONG Huijing Beijing University of Chinese Medicine, Beijing 100029, China
Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China 
 
CUI Huijuan Department of Oncology, Integrated Chinese and Western Medicine, China-Japan Friendship Hospital, Beijing 100029, China cuihj1963@sina.com 
Abstract
    Xerosis which belongs to “endogenous dryness” is one of major adverse events in ending of those patients who take EGFRIs for non-small cell lung cancer. Zizao Yangrong Decoction that is an ancient prescription used for chapping skin and tendon dryness,it can improve EGFRIs-related xerosis by nourishing yin and blood,moistening dryness and relieving itching. Under the traditional Chinese medicine theory of “endogenous dryness injuries yin”,the essence “dryness” of EGFRIs-related xerosis was regarded as the anchor,the ending skin of EGFRIs is “skin aging” which was taken as appearance,the modern pharmacology research of Zizao Yangrong Decoction was used for support. In end,the theoretical framework of Zizao Yangrong Decoction for improving EGFRIs-related xerosis was established for guiding syndrome differentiation.

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