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| Meta-analysis of kidney tonifying and blood activating therapy combined with hemodialysis in the treatment of chronic renal failure |
| Hits 560 Download times 374 Received:September 26, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.01.13 |
| Key Words
tonifying kidney and promoting blood circulation method;hemodialysis;chronic renal failure;Meta-analysis;trial sequential analysis |
| Author Name | Affiliation | E-mail | | HE Pengfei | Beijing University of Chinese Medicine, Beijing 100029, China | | | LIU Cong | Beijing University of Chinese Medicine, Beijing 100029, China | | | LI Hongdian | Beijing University of Chinese Medicine, Beijing 100029, China | | | DONG Ao | Beijing University of Chinese Medicine, Beijing 100029, China | | | DENG Yuanyuan | Beijing University of Chinese Medicine, Beijing 100029, China | | | CHEN Shu | Beijing University of Chinese Medicine, Beijing 100029, China | | | MA Yu | Department of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | ZHANG Sai | Department of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China | | | ZHANG Mianzhi | Department of Nephrology, Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China | zhangmianzhi@vip.sina.com |
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| Abstract
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| [Objective] To conduct a meta-analysis of the literature on the combination of hemodialysis with kidney tonification and blood activation method for the treatment of chronic renal failure. [Methods] Computer searched of CNKI,WangFang,Pubmed,Embase and other databases to screen randomized controlled trials of tonic kidney and blood activation method combined with hemodialysis for the treatment of chronic renal insufficiency from the time of database creation to September 7,2022. The Cochrane Risk of Bias Assessment Tool was used to evaluate the quality of the literature,and meta-analysis was performed using Review Manager 5.3 software,and Egger test was performed using Stata 14.0 software to assess publication bias,if publication bias exists,nonparametric cut and fill method is further used to evaluate the impact of bias on the results. Evidence quality evaluation of this study involving outcome indicators used GRADEprofiler 3.6 software. [Results] Fourteen relevant studies with a total of 1 316 patients,660 in the test group and 656 in the control group,were included in the literature. Meta-analysis results showed that tonifying kidney and promoting blood circulation method combined with hemodialysis was better than the simple hemodialysis group in reducing blood creatinine and urea nitrogen levels and traditional Chinese medicine(TCM) evidence score,and the combination group was better than the simple hemodialysis group in improving creatinine clearance and efficiency,and the difference was statistically significant,but the quality of evidence needs to be improved. No significant difference was seen in the incidence of adverse reactions between the two groups. The results of the publication bias test and nonparametric clipping method suggested bias in blood creatinine and urea nitrogen indicators,but the biased results did not affect the results. [Conclusion] This study demonstrated that the combination of tonifying kidney and promoting blood circulation method with hemodialysis was effective in the treatment of chronic renal failure,which could reduce Scr,BUN,TCM evidence score and improve Ccr level,and no increase in adverse effects. However,more high-quality,large-scale studies are needed for further validation. |
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