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| Review and prospect of biological markers related to heart failure with qi deficiency and blood stasis syndrome |
| Hits 410 Download times 351 Received:December 20, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2024.02.19 |
| Key Words
heart failure;qi deficiency and blood stasis syndrome;biomarker |
| Author Name | Affiliation | E-mail | | ZHANG Ludan | Center for Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China
Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SUN Yanjun | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Fanqi | Center for Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | | | ZHANG Yao | Health Management Center for Prevention of Disease, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | GAO Shengwei | Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | CHEN Xixi | Heart Center, Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao 266000, China | | | LYU Chunxiao | Center for Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | lvchunxiao1989@163.com | | HUANG Yuhong | Center for Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China | hyh101@126.com |
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| Abstract
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| Heart failure is a common cardiovascular disease with high morbidity and mortality rates worldwide. qi deficiency and blood stasis syndrome is one of the hot topics in cardiovascular disease-related syndrome research，and it can manifest as a syndrome at different stages of heart failure. The identification of specific markers of syndromes has become the focus of current research on prevention and treatment of heart failure. Markers in clinical biochemical indicators of heart failure include B-type natriuretic peptid，N-terminal pro-B-type natriuretic peptide，cardiac troponin，inflammatory biomarkers，markers of myocardial fibrosis and so on. Additionally，multi-omics technologies such as genomics，proteomics，and metabolomics have been widely applied in biomarker research to explore potential biomarkers. This article summarizes the current research status of markers in clinical biochemical indicators and multi-omics markers in the diagnosis and prognosis of heart failure with qi deficiency and blood stasis syndrome，while also discussing the problems in the “disease-syndrome combination” biomarker research method，aiming to further standardize and optimize the study of traditional Chinese medicine syndrome biomarkers. |
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