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| Clinical observation on the treatment of renal anemia patients with kidney deficiency and dampness type CKD stage 3 to 5 by Xiezhuo Yangxue Prescription and Recombinant Human Erythropoietin Injection |
| Hits 233 Download times 158 Received:August 15, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2024.03.03 |
| Key Words
renal anemia;Xiezhuo Yangxue Prescription;Recombinant Human Erythropoietin Injection;CKD stage 3 to 5 |
| Author Name | Affiliation | E-mail | | ZHANG Jing | Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | YANG Siqi | Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | HAN Yu | Department of Nephrology, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin 300120, China | | | ZHAO Xi | Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Yaoguang | Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | wangyaoguang1012@126.com |
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| Abstract
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| [Objective] To observe the interventional effects of draining and nourishing blood formula combined with recombinant human erythropoietin injection on the improvement of anemia and residual renal function in patients with chronic kidney disease(CKD) stage 3 to 5 nephrogenic anemia. [Methods] Eighty-eight patients with CKD stage 3 to 5 renal anemia attending the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from October 2020 to October 2021 were selected and divided into a control group(44 patients) and a treatment group(44 patients) according to the random number table method. The control group was treated with recombinant human erythropoietin injection and polysaccharide iron complex,and the treatment group was treated with the combination of traditional Chinese medicine to drain turbidity and nourish blood for 3 months,and the clinical efficacy,red blood cell count(RBC),hemoglobin (Hb),serum creatinine (Scr),urea nitrogen (BUN),glomerular filtration rate (eGFR),urinary microalbumin (mALB),alanine amino transferase(ALT),aspartate aminotransferase(AST) changes,symptom scores and incidence of adverse reactions. [Results] After 3 months of treatment,the total effective rate was 86.36% in the treatment group and 56.82% in the control group,and the clinical efficacy of the treatment group was better than that of the control group(P<0.05);the symptom score,RBC,Hb,Scr,BUN and mALB all improved compared with those before treatment,and the treatment group was better than the control group (P<0.05);the safety indexes of AST and ALT before and after treatment showed that the difference was not statistically significant(P>0.05). No adverse reactions were observed in both groups. [Conclusion] The combination of drainage and blood nourishment method with recombinant human erythropoietin injection can improve the clinical symptoms,improve the clinical efficacy,and delay the progression of renal function in patients with non-dialysis renal anemia in CKD stage 3 to 5,and has certain safety. |
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