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| Preventive effect and mechanism of Bushen Huayu Formula on postoperative recurrence of endometriosis with kidney deficiency and blood stasis |
| Hits 227 Download times 155 Received:September 18, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2024.03.05 |
| Key Words
Bushen Huayu Formula plus or minus;postoperative endometriosis;inflammation;anti-endometrial antibody;recurrence rate |
| Author Name | Affiliation | | KANG Wenyan | Department of Gynecology, The Fourth People's Hospital of Hengshui, Hengshui 053000, China | | QU Yuan | Department of Gynecology, The Fourth People's Hospital of Hengshui, Hengshui 053000, China | | WANG Jing | Department of Gynecology, The Fourth People's Hospital of Hengshui, Hengshui 053000, China | | GUAN He | Department of Gynecology, The Fourth People's Hospital of Hengshui, Hengshui 053000, China |
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| Abstract
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| [Objective] Study on the preventive effect and mechanism of Bushen Huayu Formula on postoperative recurrence of endometriosis with kidney deficiency and blood stasis. [Methods] A total of 320 patients with endometriosis were selected for hospital treatment and enrolled from January 2019 to January 2021 in the Fourth People's Hospital of Hengshui. The patients were divided by random number table method. 160 patients were in the conventional Western medicine group and received conventional Western medicine treatment,and 160 patients were in the Busheng Huayu Formula group,which received addition and subtraction treatment of Busheng Huayu Formula in addition to conventional Western medicine treatment. Serum sex hormones:luteinizing hormone (LH), progesterone(P) and estrogen(E2) were detected in 2 groups before and after treatment. The levels of tumor necrosis faction-A(TNF-a), vascular endothelial growth factor (VEGF),and anti-endometrial antibody (EMAb) were evaluated by verbal description score(VRS). The symptoms of dysmenorrhea and non-menstrual pelvic pain were evaluated. The clinical efficacy of the conventional Western medicine group and the Bushen Huayu Formula group were compared,and the 2-year recurrence rate of the two groups was recorded. The occurrence of adverse reactions in the two groups during treatment was recorded. [Results] The scores of dysmenorrhea and nonmenstrual pelvic pain in Bushen Huayu Formula group were lower than those in conventional Western medicine group (P<0.05). The levels of TNF-α,VEGF and EMAb in Bushen Huayu Formula group were lower than those in conventional Western medicine group (P< 0.05),the contents of LH,P and E2 in Bushen Huayu Formula group were significantly lower than those in conventional Western medicine group(P<0.05). The traditional Chinese medicine syndrome score of Bushen Huayu Formula group was significantly lower than that of conventional Western medicine group(P<0.05),the total effective rate of Bushen Huayu Formula group(97.50%) was higher than that of conventional Western medicine group(88.13%)(P<0.05),the 2-year recurrence rate of conventional Western medicine group was 12.90%,and that of Bushen Huayu Formula group was 3.21%. The recurrence rate of 2 years between the two groups was statistically significant (P<0.05). The onset time of recurrence in the Bushen Huayu Formula group was longer than that in the conventional Western medicine group(P<0.05),and no obvious adverse reactions occurred in the two groups during treatment. [Conclusion] The addition and reduction of Bushenhuayu Formula in the treatment of endometriosis with kidney deficiency and blood stasis has significant postoperative effect,which can effectively relieve dysmenorrhea and non-menstrual pelvic pain in patients and reduce the recurrence rate. Its mechanism of action may be related to its inhibition of body inflammation,reduction of VEGF and EMAb levels,and improvement of sex hormone indexes. |
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