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| Effects of lactulose and probiotics combined with Simo Decoction on intestinal motility and serum intestinal neurotransmitters in senile diabetic patients with constipatio |
| Hits 894 Download times 524 Received:September 12, 2023 |
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| DOI
10.11656/j.issn.1672-1519.2024.03.06 |
| Key Words
lactulose;microbial preparation;Simo Decoction;diabetes;constipation |
| Author Name | Affiliation | | LI Yuanyuan | Department of Endocrinology, Zhumadian Central Hospital, Zhumadian 463000, China | | SHI Xiaodi | Department of Endocrinology, Zhumadian Central Hospital, Zhumadian 463000, China | | DING Wenfeng | Department of Endocrinology, Zhumadian Central Hospital, Zhumadian 463000, China | | LU Xudong | Hebei Geriatrics Hospital, Shijiazhuang 050000, China |
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| Abstract
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| [Objective] To investigate the effects of lactudrop,probiotics combined with Simo Decoction on intestinal motility and serum intestinal neurotransmitters in senile diabetes patients with constipation. [Methods] Selection in June 2019 to June 2021 treated in Zhumadian Geriatrics Hospital 102 cases of senile diabetic patients with constipation,based on the stochastic indicator method divided the patients into observation group and control group,51 cases of control group patients give triple therapy (moser will benefit,lactulose oral liquid,bifidobacterium),51 cases on the basis of the observation group of patients in the control group given Simo Decoction for treatment. The clinical efficacy and symptom changes (frequency of spontaneous defecation,abdominal distension,abdominal pain, endless defecation,defecate difficulty scores),serum bowel to neurotransmitter[vasoactive intestinal peptide(VIP) and somatostatin (SS),gastric dynamic element(MTL),serum levels of substance P(SP),nitric oxide(NO)],gastrointestinal dynamics[sigmoid colon rectum transmission time(RSTT),left half colon transmission time(LCTT) and the right half colon transmission time(RCTT)],etc. [Results] The clinical effective rate of observation group was higher than control group(P<0.05). After treatment,the spontaneous defecation rate,abdominal distention,abdominal pain,defecation failure and defecation difficulty score in observation group were lower than those in control group(P<0.05). After treatment,the levels of VIP,SS and NO in observation group were lower than those in control group (P<0.05),and SP level in observation group was higher than that in control group(P<0.05). RSTT,LCTT and RCTT in the observation group were shorter than those in the control group(P<0.05). [Conclusion] Lactulose and probiotics combined with Simo Decoction can relieve constipation symptoms,improve intestinal motility and serum intestinal neurotransmitters in elderly diabetic patients,and have significant efficacy. |
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