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| Analysis of traditional Chinese medicine syndromes and pathological characteristics of thyroid papillary carcinoma with Hashimoto's thyroiditis |
| Hits 273 Download times 132 Received:January 12, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.05.02 |
| Key Words
thyroid papillary carcinoma;Hashimoto's thyroiditis;pathological characteristics;traditional Chinese medicine syndrome type |
| Author Name | Affiliation | E-mail | | QIAO Jiajun | Department of Chinese Medicine Surgery, China-Japan Friendship Hospital, Beijing 100029, China | | | WANG Yuezhu | Department of Chinese Medicine Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Beijing University of Chinese Medicine, Beijing 100029, China | | | LU Yuyuan | Department of Chinese Medicine Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Beijing University of Chinese Medicine, Beijing 100029, China | | | XIA Zhongyuan | Department of Chinese Medicine Surgery, China-Japan Friendship Hospital, Beijing 100029, China | 2718421708@qq.com |
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| Abstract
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| [Objective] To explore the effect of Hashimoto’s thyroiditis （HT） on the distribution of traditional Chinese medicine（TCM） syndromes and clinicopathological characteristics of thyroid papillary carcinoma（PTC） patients. [Methods] The medical records of 379 patients with thyroid papillary carcinoma who met the standard of Nabil from January 2020 to January 2022 in the China-Japan Friendship Hospital were analyzed retrospectively. The observation indicators include gender，age，four diagnostic information of traditional Chinese medicine，whether there is HT，BRAF V600E gene，the largest diameter of tumor，gland lobe involved，capsule invasion，number of tumor，whether there is microcancer，and cervical lymph node metastasis. According to the pathological results of the patients，they were divided into an observation group （i.e. PTC patients with HT） of 146 cases and a control group （i.e. PTC patients without HT） of 233 cases. SPSS 25.0 statistical software was used for analysis. [Results] Compared with control group，observation group had a higher proportion of liver stagnation and qi stagnation syndrome and spleen and kidney yang deficiency syndrome （P＜0.05），and the proportion of deficiency of both qi and yin and deficiency of both qi and blood was lower（P＜0.05）. There was no statistical difference between the two groups in the distribution of phlegm and blood stasis and yin syndrome caused by blood stasis and heat. Compared with control group，observation group had a higher proportion of women，a smaller tumor diameter，a higher proportion of multifocal lesions， and a lower proportion of cervical lymph node metastasis（P＜0.05）. However，there was no statistical difference between the two groups in the expression of BRAF V600E gene，the extent of gland lobe involved，whether it was microcarcinoma，and the invasion of capsule. Positive TPOAb antibody was associated with small tumor diameter，low BRAF V600E gene mutation rate and low cervical lymph node metastasis rate （P＜0.05）. Positive TGAb antibody was also associated with smaller tumor diameter （P＜0.05）. There was no significant correlation between TGAb positive and other pathological features. The correlation analysis between TCM syndrome types and tumor pathological characteristics showed that the spleen and kidney yang deficiency syndrome in PTC patients was highly correlated with tumor stage （P＜0.05）. Observation group was associated with high risk of recurrence （P＜0.05）. No significant correlation between TCM syndrome types and pathological characteristics of observation group has been found. The syndrome of deficiency of both qi and yin in control group was related to the multifocal tumor （P＜0.05）. [Conclusion] PTC patients with HT had a higher proportion of liver depression and qi stagnation，spleen and kidney yang deficiency syndrome types，and a lower proportion of qi yin deficiency and qi blood deficiency syndrome types. TCM syndrome types may be related to clinicopathological characteristics，tumor stage and recurrence risk. The majority of PTC patients with HT are women，and the proportion of tumor multifocal is high，but it has the advantages of small tumor size and low cervical lymph node metastasis，and the positive anti-thyroid antibody is the main related factor. |
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