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| Mechanism of sargentodoxa cuneate in treatment of hyperlipidemia based on patent data mining and network pharmacology |
| Hits 184 Download times 119 Received:January 10, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.05.18 |
| Key Words
data mining;network pharmacology;sargentodoxa cuneata;hyperlipidemia;disease-target network;mechanism of action |
| Author Name | Affiliation | E-mail | | ZHANG Xiaoxiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | ZHAN Xiujun | State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China | | | LI Xiaoge | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | JIANG Qibao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China | | | ZHANG Qingrui | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China | | | JIA Li | Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China | | | JIANG Miaomiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin 301617, China
Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-Based Chinese Medicine, Tianjin 301617, China | miaomiaojiang@126.com |
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| Abstract
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| [Objective] To explore the possible mechanism of Sargentodoxa cuneata in the treatment of hyperlipidemia by data mining and network pharmacology. [Methods] PubMed and CNKI were used to search for “chemical constituents of Sargentodoxa cuneata” or “components of Sargentodoxa cuneata” for data collection and compound screening. Origin Pro 2021 software was used to analyze the frequency of efficacy categories involving traditional Chinese medicine. SPSS Modeler 18.0 software was used for association rule analysis and cluster analysis. The Swiss ADME platform was used to predict the absorption and drug-like properties of candidate compounds. Swiss Target Prediction platform was used to collect all the predicted targets. The potential targets of hyperlipidemia in Genegards，Drug Bank Database and other databases were searched with “hyperlipidemia” and “hyperlipidemia” as keywords. The target names were removed and corrected by Uniprot database，and the intersection of active components and hyperlipidemia targets was taken. Cytoscape 3.8.0 software was used to visualize the network and screen the core target genes. GO function enrichment analysis and KEGG pathway enrichment analysis were performed through the DAVID 6.8 database to predict the mechanism of action of the intersection targets，and the mapping was visualized. [Results] Through data mining，the law of drug compatibility of sargentodoxa cuneata was analyzed. The results showed that the nature and flavor were mainly warm，cold，bitter and pungent，and the meridian was mainly liver and spleen. The compatibility was closely related to angelica，licorice and safflower. The results are consistent with the medication rule of traditional Chinese medicine in the treatment of hyperlipidemia. Traditional Chinese medicine-compound-target network contained 43 active components and 133 corresponding targets. The key targets involved RXRA，STAT3，HSP90AA1，AKT1，PIK3R1，ESR1，PPARA， NR3C1，etc. GO functional enrichment analysis obtained 437 items （P＜0.01），and KEGG pathway enrichment analysis screened 57 signal pathways （P＜0.05）. [Conclusion] Sargentodoxa cuneata can interfere with multiple targets and links in dyslipidemia through multiple active components，and participate in the regulation of lipid metabolism and the occurrence and development of hyperlipidemia from a multidimensional and systematic level. This study can provide a theoretical basis for the further development and utilization of sargentodoxa cuneata. |
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