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| Research progress on new technologies to improve bioavailability of Panax notoginseng saponins |
| Hits 244 Download times 314 Received:February 05, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.05.21 |
| Key Words
Panax notoginseng saponin;absorption and metabolism in the body;new technologies for formulations;bioavailability |
| Author Name | Affiliation | E-mail | | LU Wenmin | College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150004, China
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China | | | WANG Xi | College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150004, China
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China | | | WANG Xiangtao | College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150004, China
Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China | xtaowang@163.com |
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| Abstract
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| Panax notoginseng saponinｓ (PNS) ａre dammarane-type triterpenoid saponins extracted from the root of panax notoginseng， which have been used as natural medicines for many years because of their diverse pharmacological activities and medicinal values. However，the therapeutic potential of PNS is largely limited by their low bioavailability，mainly due to their high polarity，poor membrane permeability，instability in the gastrointestinal tract，and extensive metabolism in the body. This article reviewed the pharmacological effects，absorption and metabolic characteristics of PNS，the key factors affecting their bioavailability，effective strategies to improve their bioavailability，in order to deepen the understanding of PNS in different areas such as clinical treatment and disease prevention，to design a more efficient drug delivery system and maximize the therapeutic potential of PNS. |
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