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| Clinical observation of Qingfei Paidu Decoction combined with methylprednisolone in treating immune checkpoint inhibitor related pneumonia |
| Hits 208 Download times 143 Received:February 22, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.06.04 |
| Key Words
immune related pneumonia;immune checkpoint inhibitors;Qingfei Paidu Decoction;efficacy evaluation;clinical research |
| Author Name | Affiliation | E-mail | | LIU Beibei | Xinxiang Medical College, Xinxiang 453003, China
Gannan Health Vocational College, Ganzhou 341000, China | | | LI Fei | Ganzhou People's Hospital, Ganzhou 341000, China | | | PENG Weiwei | Ganzhou People's Hospital, Ganzhou 341000, China | | | CHEN Guorong | Xinxiang Medical College, Xinxiang 453003, China | guorongchen@xxmu.edu.cn |
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| Abstract
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| [Objective] To investigate the efficacy and safety of Qingfei Paidu Decoction combined with methylprednisolone in the treatment of patients with 2~4 grade of immune checkpoint inhibitor-related pneumonia （CIP）. [Methods] Thirty malignant tumor patients with immune pneumonia caused by ICIs were randomly divided into two groups. The control group was treated with methylprednisolone，and the combined group was treated with Qingfei Paidu Decoction and methylprednisolone. The Clinical-imaging-physiological （CRP） score，imaging efficacy evaluation，Karnofsky Performance Status （KPS） score and traditional Chinese medicine （TCM） syndrome score were compared between the two groups before and after treatment. [Results] After treatment，CRP scores in both groups were decreased，and the combined group was significantly lower than the control group （P<0.05）. The imaging manifestations of both groups were improved， and the effective rate of the combined group was 86.7% better than that of the control group 66.7%，but there was no statistical significance （P>0.05）. KPS scores in both groups were increased，and the combined group was significantly higher than the control group （P<0.05）. TCM syndrome score were decreased in both groups，and the combined group was significantly lower than the control group （P<0.05）. [Conclusion] The combination of Qingfei Paidu Decoction with methylprednisolone can improve clinical symptoms and quality of life of CIP patients，and the efficacy was better than that of methylprednisolone alone. |
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