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| Optimization of the extraction process for Chinese herbal compound Biannaitong based on Box-Behnken response surface design |
| Hits 154 Download times 127 Received:December 12, 2023 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.06.19 |
| Key Words
response surface design;extraction process;HPLC |
| Author Name | Affiliation | E-mail | | YIN Qianqian | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | DENG Xiuping | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHONG Yuhong | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xin | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xiaoying | Wuhan Tongji Modern Pharmaceutical Technology Co., Ltd., Wuhan 430056, China | | | LIU Kai | Wuhan Tongji Modern Pharmaceutical Technology Co., Ltd., Wuhan 430056, China | | | LI Jiarui | Wuhan Tongji Modern Pharmaceutical Technology Co., Ltd., Wuhan 430056, China | | | FU Moli | Wuhan Tongji Modern Pharmaceutical Technology Co., Ltd., Wuhan 430056, China | | | LIU Zhidong | State Key Laboratory of Component Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Modern Traditional Chinese Medicine Discovery and Formulation Technology Engineering Research Center of the Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | liuzhidong@tjutcm.edu.cn | | LI Yiwu | Wuhan Tongji Modern Pharmaceutical Technology Co., Ltd., Wuhan 430056, China | 450814277@qq.com |
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| Abstract
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| [Objective] To optimize the extraction process of Chinese medicine compound Biannaitong（BNT） by Box-Behnken response surface design. [Methods] Based on the single factor test，the influencing factors and range of BNT extraction process were optimized. The three-factor and three-level test design scheme was constructed by Box-Behnken response surface design method. The content of sennoside B，sennoside A and hesperidin was used as the response index to optimize the best extraction process conditions，and the process verification was carried out. [Results] The optimum extraction conditions of Chinese herbal compound BNT were as follows：solid-liquid ratio of 1∶8，reflux time of 30 min，extracting for 2 times. [Conclusion] The Box-Behnken response surface design method was used to optimize the BNT extraction process of traditional Chinese medicine compound. The method is stable and can provide a reference for the BNT extraction process. |
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