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| Study on the clinical efficacy and mechanism of acupuncture and moxibustion therapy on diabetic peripheral neuropathy patients with qi-deficiency and blood-stasis type |
| Hits 219 Download times 161 Received:February 22, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.07.12 |
| Key Words
acupuncture;moxibustion therapy;diabetic peripheral neuropathy;carotid vascular elasticity;vascular endothelial function;fibrin gelatin-3 |
| Author Name | Affiliation | E-mail | | ZHU Xiaoliang | Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | | ZHANG Yingjie | Department of Nephrology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | | GUO Liangyu | Department of Pharmacy, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | | QI Haiying | Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | | | ZHENG Xinxing | Department of Endocrinology, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao 066000, China | 545815884@qq.com |
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| Abstract
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| [Objective] To observe the effects of acupuncture combined with moxibustion therapy on carotid artery elasticity，glucose and lipid metabolism，vascular endothelium，serum HbA1c and fibrin agglutinin-3（ficolin-3） in diabetic peripheral neuropathy patients with qi-deficiency and blood-stasis type. [Methods] Ninety-two patients with diabetic peripheral neuropathy were selected for hospital treatment，and all cases were successively enrolled in the group from June 2021 to June 2023，and the grouping method was random number table. The conventional group of 30 cases was given conventional Western medicine treatment；acupuncture group（31 cases） was given acupuncture treatment on the basis of conventional treatment. Moxibustion treatment combined with 31 cases，acupuncture group was treated with moxibustion treatment. The clinical efficacy of the conventional group，acupuncture group and moxibustion therapy combined with the group was compared. The patients were given diarrhea or constipation，fatigue and lethargy，pain at the end of the limb and pain at night，sweating when moving，numbness and weakness in the limb，shortness of breath and lazy speech before and after treatment. The common carotid artery pressure strain elastic modulus was detected. The levels of nitric oxide（NO），endothelin（ET），triglyceride（TG），HbA1c，ficolin-3 and high-density lipoprotein（HDL-C） were detected. [Results] The total effective rate in moxibustion group and acupuncture group was higher than that in conventional group（P<0.05）. In the combination group of moxibustion therapy，diarrhea or constipation，exhaustion，pain at the end of the limb，pain at night，sweating after movement，and ants in the limb and numbness and weakness，shortness of breath and lazy speech score were lower than those in the conventional group and acupuncture group（P<0.05）. In the acupuncture group，diarrhea or constipation，exhaustion，pain at the end of the limb and pain at night，movement，sweating，and ants in the limb and numbness and weakness，the score of shortness of breath and lazy speech was lower than that of normal group（P<0.05）；the common carotid artery pressure strain elastic modulus in combination group was lower than that in conventional group and acupuncture group（P<0.05），and the common carotid artery pressure strain elastic modulus in acupuncture group was lower than that in conventional group（P<0.05）. The expression level of HDL-C in laying moxibustion therapy with the group was higher than that in conventional group and acupuncture group（P<0.05）. The expression level of HDL-C in acupuncture group was higher than that in conventional group and acupuncture group（P<0.05），and the expression level of TG and HbA1c in laying moxibustion therapy with the group was lower than that in conventional group and acupuncture group（P<0.05）. The expression levels of TG and HbA1c in acupuncture group were lower than those in conventional group（P<0.05）. The expression levels of ficolin-3 and NO in moxibustion combined group were higher than those in conventional group and acupuncture group（P<0.05）. The expression levels of ficolin-3 and NO in laying moxibustion therapy with the group were higher than those in conventional group and acupuncture group（P<0.05），and the expression levels of ET in laying moxibustion therapy with the group were lower than those in conventional group and acupuncture group（P<0.05）. The acupuncture group’s expression level of ET was lower than conventional group（P<0.05）. [Conclusion] Moxibustion treatment combined acupuncture in patients with diabetic peripheral neuropathy can improve glucose and lipid metabolism，carotid vascular elasticity，vascular endothelial function，enhance ficolin-3 level，alleviate the disease and improve clinical efficacy. |
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