|
| Preventive effect of Compound Danshen Dripping Pill on contrast nephropathy after percutaneous coronary intervention among the patients with coronary artery disease complicated with diabetes mellitus |
| Hits 208 Download times 136 Received:March 18, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.08.03 |
| Key Words
Compound Danshen Dripping Pill;contrast nephropathy;percutaneous coronary intervention;coronary artery disease;diabetes mellitus;prevent |
| Author Name | Affiliation | E-mail | | XI Pengli | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China | | | YANG Shicheng | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China | | | GONG Xincheng | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China | | | YING Shuo | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China | | | ZHANG Peng | Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, China | peng306588_0@163.com |
|
| Abstract
|
| [Objective] To investigate the protective effect of Compound Danshen Dripping Pills on contrast-induced acute kidney injury（CIAKI） among the patients with coronary artery disease complicated with diabetes. [Methods] One hundred and eighty patients with diabetes and coronary artery disease who were admitted in Tianjin Chest Hospital from January，2022 to January，2023 and scheduled for interventional therapy were randomly divided into observe group（90），receiving additional Compound Danshen Dripping Pills on the basis of the control group，and the control group（90），receiving hydration therapy to prevent CIN. The incidence of contrast nephropathy rate，and the renal function of the two groups before and 72 hours after treatment was compared. The levels of renal function indexes（BUN，Scr，eGFR，β2-microglobulin，ACR and NGAL），inflammatory reaction indexes（hs-CRP，IL-6），and oxidative stress indexes（malondialdehyde and SOD） were measured before and after treatment. The patients were followed up 6 months and record the occurrence of major adverse cardiac events（MACE） in both groups. [Results] 1） The treatment group had statistically lower incidence of CIAKI than the control group（4.4% vs 16.7%，P<0.05）. 2） Before treatment，no significant differences of clinical background factors between the two groups were found（P >0.05）. The levels of Scr，BUN，β2-microglobulin，hs-CRP，IL-6，malondialdehyde，protein-creatinine ratio（ACR） and neutrophil gelatinase associated lipocalin（NGAL） were significantly increased，while the eGFR and SOD were obviously decreased in both groups in 72 h after treatment（P<0.05）. In 72 h after treatment，the levels of Scr，BUN，β2-microglobulin，hs-CRP，IL-6，malondialdehyde，protein-creatinine ratio（ACR） and neutrophil gelatinase associated lipocalin（NGAL） were notably lower，and the eGFR and SOD were remarkably higher in the Compound Danshen Dripping Pills group than the control group（all P<0.05）. 3） Following up for 6 months，the incidence of adverse prognosis in the Compound Danshen Dripping Pills group was lower than that in control group，with significant difference（10.0% vs 31.3%，P<0.05）. 4） Multivariate logistic regression analysis showed that Compound Danshen Dripping Pills had positive effect on the prevention of CIAKI [OR=0.136，95%CI（0.035，0.527），P=0.004]. [Conclusion] Compound Danshen Dripping Pills may exert certain preventive effect on the development of CIAKI among the patients with diabetes and coronary artery disease in the interventional therapy. |
|
|
|
|
|
|
|
