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| Exploring the mechanism of action of irisin in knee osteoarthritis based on the “muscle-bone balance” concept |
| Hits 70 Download times 40 Received:March 13, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.09.10 |
| Key Words
knee osteoarthritis;muscle-bone balance;irisin |
| Author Name | Affiliation | E-mail | | ZHANG Longyao | Orthopedics Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Xiao | National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China
Cardiovascular Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China | | | XU Jiankang | Orthopedics Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | WANG Ping | Orthopedics Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | | | ZHANG Chao | Orthopedics Department, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China
National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China | zhangchao2004.love@163.com |
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| Abstract
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| This study aims to explore the mechanism of action of irisin in knee osteoarthritis （ＫＯＡ）by analyzing the “muscle-bone balance” theory. Irisin，as a muscle-secreted factor，has the potential to promote chondrocyte proliferation and inhibit muscle degeneration，demonstrating significant potential for arthritis treatment. This paper discusses the regulatory mechanisms of irisin on muscle-bone metabolism，thereby investigating the relevance of irisin to the “muscle-bone balance” theory and exploring its potential application in the treatment of KOA. The study aims to provide modern medical support for this theory，supporting and expanding the application of the “muscle-bone balance” concept，and offering new therapeutic approaches to improve KOA management. |
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