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| The mechanism of Xuanfei Baidu Granules to treat influenza virus pneumonia by increasing T cells |
| Hits 74 Download times 40 Received:May 27, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.10.14 |
| Key Words
Xuanfei Baidu Granules;influenza virus(A/PR/8/34);influenza virus pneumonia;T cell |
| Author Name | Affiliation | E-mail | | YUAN Ye | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MA Lin | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Qianru | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHAO Ronghua | China Academy of Chinese Medical Sciences, Beijing 100091, China | | | FANG Qingdi | Tsinghua University, Beijing 100084, China | | | WANG Yu | State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | wangyu@tjutcm.edu.cn |
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| Abstract
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| [Objective] To establish a influenza virus(A/PR/8/34) pneumonia model under low temperature and high humidity,and evaluate the efficacy and mechanism of Xuanfei Baidu Granules(XFBD) against influenza. [Methods] ICR mice were placed in an artificial climate box with low temperature and high humidity,and influenza virus(A/PR/8/34) was given intranasally. On the 5th day after modeling,mice were given XFBD by gavage for 5 d. The behavioral score,body weight,organ index,pulmonary viral load,pulmonary imaging and morphological changes were observed and recorded. The expression of NF-κB,a key inflammatory protein, was detected by Western blot,and the regulation of XFBD on the immune response of mice was detected by flow cytometry. [Results] Compared with the model group,after administration of XFBD,mice showed increased activity,normal stool characteristics,decreased lung viral load,decreased inflammatory exudation in mice’s lungs,decreased expression of p-NF-κB P65,and increased percentages of CD4+ and CD8+T cells. [Conclusion] XFBD increased the amount of T cells,and inhibited the inflammation of the influenza virus pneumonia under cold and high humidity conditions. |
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