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| Study on correlation between traditional Chinese medicine syndrome types and the stability of layered plaques evaluated by intracoronary optical coherence tomography |
| Hits 10 Download times 3 Received:August 07, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.11.01 |
| Key Words
optical coherence tomography;coronary heart disease;layered plaque;traditional Chinese medicine syndrome types;qi deficiency and blood stasis syndrome |
| Author Name | Affiliation | E-mail | | JIA Jingyun | Beijing University of Chinese Medicine, Beijing 100029, China | | | CHEN Buxing | The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China | chbux@126.com |
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| Abstract
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| [Objective] To evaluate the correlation between the stability of layered plaques and traditional Chinese medicine(TCM) syndrome types by coronary optical coherence tomography. [Methods] A case-control study was conducted to investigate 124 patients diagnosed with coronary heart disease in the Department of Cardiology of the Third Affiliated Hospital of Beijing University of Chinese Medicine from August 2022 to August 2023. Coronary optical coherence tomography was performed and relevant image data were obtained. TCM syndrome diagnosis was performed according to the relevant guidelines. Firstly,the Chi-square test was conducted to select the significant TCM syndrome types with the TCM syndrome types as independent variables and whether the coronary plaque was layered as the dependent variable. Secondly,with TCM syndrome types as independent variables and whether the coronary layered plaque was multi-layered as the dependent variable,Chi-square test was performed to screen out the TCM syndrome types associated with multi-layered plaques. Finally,the number of layered plaques with unstable characteristics was compared between the two groups according to the TCM syndrome types related to multi-layered plaques as grouping standard. SPSS 26.0 software was used for statistical analysis. [Results] Among the 124 patients,the proportion of heart and kidney yin deficiency syndrome(41 cases,37%),and qi deficiency and blood stasis syndrome(37 cases,33%) were relatively high. The patients were divided into the layered plaque group(n=83) and the non-layered plaque group(n=41) according to the presence or absence of the layered coronary plaque,and the Chi-square test was performed with different syndrome types. The test results showed that there was a significant correlation between coronary layered plaques and qi deficiency and blood stasis syndrome(P<0.05,OR=2.75). The layered plaque group was further divided into the single-layered plaque group(n=40) and the multi-layered plaque group(n=43) and the Chi-square test was performed. The results of Chi-square test showed that there was a significant correlation between qi deficiency and blood stasis syndrome and coronary artery multi-layered plaque(P<0.05,OR=3.29). By comparing the stability of coronary layered plaques between patients with qi deficiency and blood stasis syndrome and patients with non-qi deficiency and blood stasis syndrome in the layered plaque group,the average number of thin fibrous cap atherosclerotic layered plaques and thin fibrous cap layered plaques were(1.24±0.87) and(2.07±1.05) respectively in patients with qi deficiency and blood stasis syndrome. The number of layered plaques with unstable characteristics was more than that in patients with non-qi deficiency and blood stasis syndrome(P<0.01). [Conclusion] Qi deficiency and blood stasis syndrome has a certain correlation with the stability of coronary layered plaques. Whether the clinical application of traditional Chinese medicine in the treatment of coronary heart disease from supplementing qi,activating blood and removing blood stasis can better improve the stability of coronary layered plaque is worthy of further exploration. |
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