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| Effects of addition and reduction of Longdan Xiegan Decoction on anti-fibrosis improvement，viral load，serum HBsAg and ADA in chronic hepatitis B hypoviriemia |
| Hits 16 Download times 10 Received:July 27, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2024.11.02 |
| Key Words
Longdan Xiegan Decoction;chronic hepatitis B;hypoviremia;immune function;anti-fibrosis;viral load |
| Author Name | Affiliation | E-mail | | XU Yuxuan | Hebei University of Chinese Medicine, Shijiazhuang 050091, China | | | NIU Jianhai | Department of Splenology and Gastroenterology, First Chinese Medicine Hospital of Baoding City, Baoding 071000, China | xuyuxuany008@163.com | | GAO Huan | Department of Splenology and Gastroenterology, First Chinese Medicine Hospital of Baoding City, Baoding 071000, China | |
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| Abstract
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| [Objective] To observe the effects of Longdan Xiegan Decoction on anti-fibrosis improvement,viral load,serum HBsAg,and ADA in chronic hepatitis B hypoviremia. [Methods] A total of 102 patients with chronic hepatitis B treated in the hospital were selected,and all patients were enrolled from January 2020 to January 2023. The patients were grouped by the random number table method. The 52 cases in the Western medicine group were given entecavir tablets,and 50 cases in the Chinese and Western medicine group were given Longdan Xiegan Decoction plus subtraction treatment,comparing the clinical efficacy of the Western medicine group and the Chinese and Western medicine group. The clinical efficacy of the Western medicine group and the Chinese and Western medicine group was compared. Before and after treatment,the patients were evaluated for yellowing of body and eyes,epigastric depression and abdominal distension,hypochondriac pain,yellow urine,irritability and heat,dry and bitter mouth,drowsiness and fatigue,loss of appetite,itchy skin,nausea and vomiting,constipation or loose stool. The levels of hepatitis B virus(HBV)-DNA,Hepatitis B surface antigen(HBsAg),adenosine deaminase(ADA),total bilirubin,HbsAg,CD4+/CD8+,type Ⅲ collagen,hyaluronic acid,interleukin-27(IL-27) were detected,and the negative conversion rate of HBV-DNA and HBsAg were calculated. [Results] The total effective rate of the Chinese and Western medicine group was 96.00%,the total effective rate of Western medicine group was 80.77%,and the total effective rate of the Chinese and Western medicine group was higher than that of Western medicine group(P<0.05). Compared with Western medicine group,the scores of the Chinese and Western medicine group were lower than those of the Western medicine group(P<0.05). The levels of HBV-DNA and HBsAg in the Chinese and Western medicine group were lower than those in Western medicine group(P<0.05),and the negative conversion rates of HBV-DNA and HBsAg in the Chinese and Western medicine group were higher than those in Western medicine group(P<0.05). The levels of ADA,total bilirubin,type Ⅲ collagen,and hyaluronic acid in the Chinese and Western medicine group were lower than those in the Western medicine group(P<0.05);CD4+/CD8+ in the Chinese and Western medicine group was higher than that in Western medicine group(P<0.05),and IL-27 level in Chinese and Western medicine group was lower than that in Western medicine group(P<0.05). [Conclusion] In the treatment of patients with chronic hepatitis B hypoviraemia,Longdan Xiegan Decoction can improve immune function,inhibit inflammation,enhance anti-fibrosis ability,reduce viral load and serum HBsAg and ADA levels,alleviate disease,and improve clinical efficacy. |
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