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| Research progress in traditional Chinese medicine regulating mitochondrial aberration for the treatment of HFpEF |
| Hits 4 Download times 1 Received:July 26, 2024 |
| View Full Text View/Add Comment Download reader |
| DOI
10.11656/j.issn.1672-1519.2024.11.19 |
| Key Words
heart failure with preserved ejection fraction;mitochondrial aberration;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | MA Yaolei | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Xiao | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LI Tiantian | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | HUANG Xianglong | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | ZHANG Han | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | zhanghan0023@126.com | | LEI Wei | Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | l_wei8910@163.com |
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| Abstract
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| Heart failure(HF) is currently one of the diseases with most morbidity and mortality rates in the world. Among them,HF with preserved EF(HFpEF) accounts for a relatively high proportion of HF,and the current clinical treatment methods are still only to improve clinical symptoms,but cannot effectively treat the disease itself and reduce mortality due to HF. The prominent feature of HFpEF are diastolic dysfunction and ventricular muscle remodeling,and the remodeling of ventricular muscle is closely related to mitochondrial aberration. Therefore,this article reviews the key target proteins that lead to mitochondrial aberrations in HFpEF,such as mitochondrial biogenesis disorders,mitochondrial fission/fusion kinetic disorders,and mitochondrial autophagy abnormalities,and the mechanism and clinical research of traditional Chinese medicine with the effect of "replenishing qi and assisting yang" on HFpEF. To summarize and analyze the traditional Chinese medicine(TCM) compounds or active ingredients that can be used for the treatment of HFpEF,so as to provide a reference for the effective treatment of HFpEF by TCM,and also to provide a direction for the development of new HFpEF specific drugs. |
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