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Effect of biological rhythm on prevention and treatment of liver cancer based on traditional Chinese medicine time medicine
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DOI   10.11656/j.issn.1672-1519.2025.01.21
Key Words   traditional Chinese medicine time medicine;liver cancer;biological rhythm;biological clock;chronotherapy
Author NameAffiliationE-mail
ZHU Yihua New Technologies of Bone Injury Repair and Reconstruction Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China  
WANG Lining New Technologies of Bone Injury Repair and Reconstruction Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China
College of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China 
 
LI Xiaoyue Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210037, China  
LI Liqiu Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210037, China  
LI Shangzhen Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine, Nanjing 210037, China  
LI Muzhe New Technologies of Bone Injury Repair and Reconstruction Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China  
ZHANG Tianchi New Technologies of Bone Injury Repair and Reconstruction Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China  
MA Yong New Technologies of Bone Injury Repair and Reconstruction Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, China
College of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China
Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng TCM Hospital, Yancheng 224001, China 
 
YI Yongxiang Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing Drum Tower Hospital, Nanjing 210008, China ian0126@126.com 
Abstract
    Traditional Chinese medicine time medicine is the study of the relationship between natural time rhythms and cyclical biological rhythms of the human body based on the core principle of “correspondence of human body and nature environment”,which guides the prevention,diagnosis,treatment and prognosis of diseases. Liver cancer is the third most common cause of cancer-related deaths in the world with a serious threat to human health. The liver as “official of the general” with yang for yin function governs conveyance and dispersion,and the rhythmic nature of the liver’s function is reflected in its regulation of various biological rhythms,including rest,diet and work. Therefore,the disruption of the biological rhythm inevitably plays a promoting role in the development and deterioration of liver cancer. The review discusses the correlation between liver and biological rhythm from the perspective of traditional Chinese medicine time medicine,specifies the influence of rest and diet rhythm on liver development,and discusses the application of liver cancer chronotherapy in conjunction with modern biological clock concept,hoping to enrich the clinical knowledge of liver cancer and provide some potential effective treatment options.

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