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| Research on the toxic effects and rules of neurotoxic traditional Chinese medicine based on traditional Chinese medicine system toxicology database |
| Hits 28 Download times 12 Received:August 25, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.02.10 |
| Key Words
traditional Chinese medicine;neurotoxicity;mechanism of action;law research;traditional chinese medicine system toxicology database |
| Author Name | Affiliation | E-mail | | LIU Wei | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | MA Ning | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | QIAN Wenxiu | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | LIU Huimin | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | | | SONG Lili | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | sll0204@163.com | | LI Yubo | College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China | yaowufenxi001@sina.com |
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| Abstract
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| [Objective] To explore the effect and regularity of neurotoxicity induced by traditional Chinese medicine，and to provide reference for the study of neurotoxicity of traditional Chinese medicine. [Methods] Based on the traditional Chinese medicine system toxicology database（TCMSTD），252 kinds of medicinal materials were screened and analyzed，and the toxic effects，taste and meridian tropism of traditional Chinese medicine with neurotoxicity were summarized. [Results] AThere were 56 kinds of drugs with neurotoxicity. The main toxic effects were central excitation，central inhibition，pupil enlargement，unconsciousness，irritability，dizziness，convulsion，paralysis and coma. The drug properties with neurotoxicity are mainly warm and cold，and the meridian tropism of drugs is mainly liver and heart. The main effects are clearing heat，external use，resolving phlegm，relieving cough and asthma. [Conclusion] In this paper， 56 kinds of neurotoxicity drugs summarized based on TCMSTD database were analyzed and summarized，in order to help reduce and control their neurotoxicity，lay a foundation for the establishment of non-toxic drug regimen of toxic traditional Chinese medicine，and provide reference for its attenuated drug use in clinic. |
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