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| Advances in the studies of endophyte’s metabolites and their pharmacological activities from traditional Chinese medicine |
| Hits 25 Download times 8 Received:August 27, 2024 |
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| DOI
10.11656/j.issn.1672-1519.2025.02.19 |
| Key Words
endophyte;metabolite;pharmacological activity;traditional Chinese medicine |
| Author Name | Affiliation | E-mail | | LIU Mei | School of Pharmaceutical Science, University of South China, Hengyang 421001, China
Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China | | | PENG Yuhui | Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China | | | PU Hong | Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China | | | LIU Jianxin | School of Pharmaceutical Science, University of South China, Hengyang 421001, China
Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery System, Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China
Institute of Innovation and Applied Research in Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China | liujianxin3385@126.com |
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| Abstract
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| The metabolites of endophytic bacteria in traditional Chinese medicine are important sources of lead compounds，which have become a research hotspot in the field of pharmacy. In this review，we summarized the main endophytes found in plants in recent years and analyzed their metabolites and metabolites’ pharmacological activities. It was found that endophytes could produce the same effective ingredients as natural drugs，mainly including terpenoids，alkaloids，and anthraquinones. The results of pharmacological activity tests showed that the metabolites of endophytic bacteria had significant pharmacological activities，mainly in anti-pathogenic microorganisms，anti-tumor，and anti-inflammatory，which provided a reference and new way for the discovery and research of lead compounds. It is worth noting that endophytes have also been proven to be beneficial to the growth of medicinal plants，and even improve the resistance of medicinal plants to diseases and insects，which provides new ideas for the improved cultivation of medicinal plants. |
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